Matches in SemOpenAlex for { <https://semopenalex.org/work/W2463432273> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2463432273 endingPage "15" @default.
- W2463432273 startingPage "1" @default.
- W2463432273 abstract "ABSTRACT The circadian rhythm of compound action potentials (CAP) frequency recorded from the isolated eye of Aplysia in culture medium and darkness was subjected to step and pulse treatments with anisomycin, a protein synthesis inhibitor. The step application of anisomycin and its continued presence in the culture medium lengthened the period of the rhythm in a dose-dependent manner. At 10−8 M the period was increased from the normal 26·5 h to about 28 h and at io-7 M the period was lengthened to 31 h or longer. At 10−7 M the rhythm was suppressed but the CAP activity continued without the cyclic variations in CAP frequency. Six-hour pulses of anisomycin at 10−8 M caused phase-dependent phase-shifts of the rhythm. Maximum phase delays of 15 h were obtained at CT (circadian time) 2 and maximum phase advances of 4 h were obtained at CT 6. The phase response curves at 12, 15 and 17 °C were essentially identical. Anisomycin appears to act rather selectively on the circadian clock mechanism. It does not alter the CAP amplitude and duration and it does not alter the bursting pacemaker mechanism of the optic nerve CAP or central neurones. The results support the hypothesis that the synthesis of a protein or polypeptide on eucaryotic ribosomes is an essential part of the circadian clock timing mechanism. The sensitivity of the clock to anisomycin is the same at three different temperatures (12, 15 and 17 °C) within the physiological range of temperatures for Aplysia, as expected for a clock whose period length is temperature compensated (Q10 1·02) over that same range. At the critical phases of CT 1–4, anisomycin pulses often caused unusual perturbations of the rhythm. These effects are consistent with the hypothesis that the circadian rhythm is a multioscillator system." @default.
- W2463432273 created "2016-07-22" @default.
- W2463432273 creator A5061613070 @default.
- W2463432273 date "1980-02-01" @default.
- W2463432273 modified "2023-09-29" @default.
- W2463432273 title "Circadian Rhythm from the Eye of <i>Aplysia</i>: Temperature Compensation of the Effects of Protein Synthesis Inhibitors" @default.
- W2463432273 cites W1489055368 @default.
- W2463432273 cites W1940744810 @default.
- W2463432273 cites W1963706706 @default.
- W2463432273 cites W2016673894 @default.
- W2463432273 cites W2047692367 @default.
- W2463432273 cites W2061836636 @default.
- W2463432273 cites W2081172239 @default.
- W2463432273 cites W2089447040 @default.
- W2463432273 cites W2093085877 @default.
- W2463432273 cites W2095120613 @default.
- W2463432273 cites W2123117862 @default.
- W2463432273 cites W2150368647 @default.
- W2463432273 cites W2336989278 @default.
- W2463432273 cites W2414057266 @default.
- W2463432273 cites W2528505911 @default.
- W2463432273 cites W46928723 @default.
- W2463432273 doi "https://doi.org/10.1242/jeb.84.1.1" @default.
- W2463432273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7365411" @default.
- W2463432273 hasPublicationYear "1980" @default.
- W2463432273 type Work @default.
- W2463432273 sameAs 2463432273 @default.
- W2463432273 citedByCount "28" @default.
- W2463432273 crossrefType "journal-article" @default.
- W2463432273 hasAuthorship W2463432273A5061613070 @default.
- W2463432273 hasBestOaLocation W24634322731 @default.
- W2463432273 hasConcept C121332964 @default.
- W2463432273 hasConcept C121446783 @default.
- W2463432273 hasConcept C12554922 @default.
- W2463432273 hasConcept C126322002 @default.
- W2463432273 hasConcept C134018914 @default.
- W2463432273 hasConcept C135343436 @default.
- W2463432273 hasConcept C169760540 @default.
- W2463432273 hasConcept C185592680 @default.
- W2463432273 hasConcept C195221683 @default.
- W2463432273 hasConcept C24890656 @default.
- W2463432273 hasConcept C2778073123 @default.
- W2463432273 hasConcept C2778178740 @default.
- W2463432273 hasConcept C2779027399 @default.
- W2463432273 hasConcept C2781291010 @default.
- W2463432273 hasConcept C3675279 @default.
- W2463432273 hasConcept C38606739 @default.
- W2463432273 hasConcept C55493867 @default.
- W2463432273 hasConcept C59822182 @default.
- W2463432273 hasConcept C63531555 @default.
- W2463432273 hasConcept C71924100 @default.
- W2463432273 hasConcept C86803240 @default.
- W2463432273 hasConceptScore W2463432273C121332964 @default.
- W2463432273 hasConceptScore W2463432273C121446783 @default.
- W2463432273 hasConceptScore W2463432273C12554922 @default.
- W2463432273 hasConceptScore W2463432273C126322002 @default.
- W2463432273 hasConceptScore W2463432273C134018914 @default.
- W2463432273 hasConceptScore W2463432273C135343436 @default.
- W2463432273 hasConceptScore W2463432273C169760540 @default.
- W2463432273 hasConceptScore W2463432273C185592680 @default.
- W2463432273 hasConceptScore W2463432273C195221683 @default.
- W2463432273 hasConceptScore W2463432273C24890656 @default.
- W2463432273 hasConceptScore W2463432273C2778073123 @default.
- W2463432273 hasConceptScore W2463432273C2778178740 @default.
- W2463432273 hasConceptScore W2463432273C2779027399 @default.
- W2463432273 hasConceptScore W2463432273C2781291010 @default.
- W2463432273 hasConceptScore W2463432273C3675279 @default.
- W2463432273 hasConceptScore W2463432273C38606739 @default.
- W2463432273 hasConceptScore W2463432273C55493867 @default.
- W2463432273 hasConceptScore W2463432273C59822182 @default.
- W2463432273 hasConceptScore W2463432273C63531555 @default.
- W2463432273 hasConceptScore W2463432273C71924100 @default.
- W2463432273 hasConceptScore W2463432273C86803240 @default.
- W2463432273 hasIssue "1" @default.
- W2463432273 hasLocation W24634322731 @default.
- W2463432273 hasLocation W24634322732 @default.
- W2463432273 hasOpenAccess W2463432273 @default.
- W2463432273 hasPrimaryLocation W24634322731 @default.
- W2463432273 hasRelatedWork W2078940583 @default.
- W2463432273 hasRelatedWork W2093085877 @default.
- W2463432273 hasRelatedWork W2093900634 @default.
- W2463432273 hasRelatedWork W2139785595 @default.
- W2463432273 hasRelatedWork W2276656060 @default.
- W2463432273 hasRelatedWork W2410501067 @default.
- W2463432273 hasRelatedWork W2463432273 @default.
- W2463432273 hasRelatedWork W3206121223 @default.
- W2463432273 hasRelatedWork W156513964 @default.
- W2463432273 hasRelatedWork W2013916420 @default.
- W2463432273 hasVolume "84" @default.
- W2463432273 isParatext "false" @default.
- W2463432273 isRetracted "false" @default.
- W2463432273 magId "2463432273" @default.
- W2463432273 workType "article" @default.