Matches in SemOpenAlex for { <https://semopenalex.org/work/W2463463882> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2463463882 endingPage "918" @default.
- W2463463882 startingPage "914" @default.
- W2463463882 abstract "In order to elucidate the relationships between the antitumor activity and the molecular structure of novel acridine derivatives (la-f, and 2a-e in Chart 1) the DNA-binding properties (intercalation) of the derivatives were examined by the quenching in fluorescence of an ethidium-DNA complex, which may be caused by the displacement of DNA-bound ethidium by a second DNA-binding ligand, acridines. The concentration (C50 value) of the acridine necessary to reduce the initial fluorescence of DNA-bound ethidium by 50% showed a good correlation with their antitumor activities. The fluorescence quenching of the acridines was examined using 4'-(9-acridinylamino)-methanesulfonanilide (amsacrine, AMSA) as a typical standard of the second DNA-bound ligand, and calf thymus DNA with an apparent site size of two base pairs." @default.
- W2463463882 created "2016-07-22" @default.
- W2463463882 creator A5035212958 @default.
- W2463463882 date "1992-01-01" @default.
- W2463463882 modified "2023-09-25" @default.
- W2463463882 title "Quenching of Ethidium-DNA Fluorescence by Novel Acridines with Antitumor Activities" @default.
- W2463463882 doi "https://doi.org/10.1248/yakushi1947.112.12_914" @default.
- W2463463882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1294716" @default.
- W2463463882 hasPublicationYear "1992" @default.
- W2463463882 type Work @default.
- W2463463882 sameAs 2463463882 @default.
- W2463463882 citedByCount "5" @default.
- W2463463882 countsByYear W24634638822016 @default.
- W2463463882 crossrefType "journal-article" @default.
- W2463463882 hasAuthorship W2463463882A5035212958 @default.
- W2463463882 hasBestOaLocation W24634638821 @default.
- W2463463882 hasConcept C116569031 @default.
- W2463463882 hasConcept C121332964 @default.
- W2463463882 hasConcept C121745418 @default.
- W2463463882 hasConcept C137824038 @default.
- W2463463882 hasConcept C147897179 @default.
- W2463463882 hasConcept C170493617 @default.
- W2463463882 hasConcept C178790620 @default.
- W2463463882 hasConcept C185581394 @default.
- W2463463882 hasConcept C185592680 @default.
- W2463463882 hasConcept C2776907736 @default.
- W2463463882 hasConcept C2776924795 @default.
- W2463463882 hasConcept C2780500152 @default.
- W2463463882 hasConcept C2910410043 @default.
- W2463463882 hasConcept C552990157 @default.
- W2463463882 hasConcept C55493867 @default.
- W2463463882 hasConcept C62520636 @default.
- W2463463882 hasConcept C71240020 @default.
- W2463463882 hasConcept C91881484 @default.
- W2463463882 hasConceptScore W2463463882C116569031 @default.
- W2463463882 hasConceptScore W2463463882C121332964 @default.
- W2463463882 hasConceptScore W2463463882C121745418 @default.
- W2463463882 hasConceptScore W2463463882C137824038 @default.
- W2463463882 hasConceptScore W2463463882C147897179 @default.
- W2463463882 hasConceptScore W2463463882C170493617 @default.
- W2463463882 hasConceptScore W2463463882C178790620 @default.
- W2463463882 hasConceptScore W2463463882C185581394 @default.
- W2463463882 hasConceptScore W2463463882C185592680 @default.
- W2463463882 hasConceptScore W2463463882C2776907736 @default.
- W2463463882 hasConceptScore W2463463882C2776924795 @default.
- W2463463882 hasConceptScore W2463463882C2780500152 @default.
- W2463463882 hasConceptScore W2463463882C2910410043 @default.
- W2463463882 hasConceptScore W2463463882C552990157 @default.
- W2463463882 hasConceptScore W2463463882C55493867 @default.
- W2463463882 hasConceptScore W2463463882C62520636 @default.
- W2463463882 hasConceptScore W2463463882C71240020 @default.
- W2463463882 hasConceptScore W2463463882C91881484 @default.
- W2463463882 hasIssue "12" @default.
- W2463463882 hasLocation W24634638821 @default.
- W2463463882 hasLocation W24634638822 @default.
- W2463463882 hasOpenAccess W2463463882 @default.
- W2463463882 hasPrimaryLocation W24634638821 @default.
- W2463463882 hasRelatedWork W1973201582 @default.
- W2463463882 hasRelatedWork W2014759166 @default.
- W2463463882 hasRelatedWork W2030917821 @default.
- W2463463882 hasRelatedWork W2059857676 @default.
- W2463463882 hasRelatedWork W2091820710 @default.
- W2463463882 hasRelatedWork W2414084544 @default.
- W2463463882 hasRelatedWork W2414821930 @default.
- W2463463882 hasRelatedWork W2745426438 @default.
- W2463463882 hasRelatedWork W2982618965 @default.
- W2463463882 hasRelatedWork W3028125919 @default.
- W2463463882 hasVolume "112" @default.
- W2463463882 isParatext "false" @default.
- W2463463882 isRetracted "false" @default.
- W2463463882 magId "2463463882" @default.
- W2463463882 workType "article" @default.