Matches in SemOpenAlex for { <https://semopenalex.org/work/W2463488392> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2463488392 endingPage "4" @default.
- W2463488392 startingPage "441" @default.
- W2463488392 abstract "In this paper, we formulate the hypothesis that in the process of target cell lysis a lysosomal enzyme regurgitation, performed by killer cells at the level of the target effector junction, accounts for the target lesion which precedes the lysis (lethal hit). This process of exocytosis, similar to the one described previously in polymorphonuclear neutrophils is supported by cytological studies performed directly on identified killers isolated by micromanipulation. Light and electron microscopy observations confirm a previous report which describes the effector cells rich in lysosomal bodies. In addition, when a killer cell is associated with a target cell to form a conjugate, lysosomes are concentrated near the cell junction and, after incubation at 37 degrees C, acid phosphatases may be detected at the junction. Lysosomal enzyme exocytosis explains why target lysis needs an effector target binding to occur and also the other conditions required for any exocytosis process such as Ca++ in the medium, integrity of the microtubular apparatus, a low level of cyclic AMP and energy dependancy." @default.
- W2463488392 created "2016-07-22" @default.
- W2463488392 creator A5001882766 @default.
- W2463488392 creator A5002662598 @default.
- W2463488392 creator A5010755138 @default.
- W2463488392 creator A5062261075 @default.
- W2463488392 creator A5085509520 @default.
- W2463488392 creator A5090132643 @default.
- W2463488392 date "1979-01-29" @default.
- W2463488392 modified "2023-09-27" @default.
- W2463488392 title "[Is the process of localized lysosomal exocytosis responsible for the cytolytic action of killer T-lymphocytes?]." @default.
- W2463488392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/109226" @default.
- W2463488392 hasPublicationYear "1979" @default.
- W2463488392 type Work @default.
- W2463488392 sameAs 2463488392 @default.
- W2463488392 citedByCount "0" @default.
- W2463488392 crossrefType "journal-article" @default.
- W2463488392 hasAuthorship W2463488392A5001882766 @default.
- W2463488392 hasAuthorship W2463488392A5002662598 @default.
- W2463488392 hasAuthorship W2463488392A5010755138 @default.
- W2463488392 hasAuthorship W2463488392A5062261075 @default.
- W2463488392 hasAuthorship W2463488392A5085509520 @default.
- W2463488392 hasAuthorship W2463488392A5090132643 @default.
- W2463488392 hasConcept C109316439 @default.
- W2463488392 hasConcept C1491633281 @default.
- W2463488392 hasConcept C175969161 @default.
- W2463488392 hasConcept C181199279 @default.
- W2463488392 hasConcept C202751555 @default.
- W2463488392 hasConcept C203014093 @default.
- W2463488392 hasConcept C2780216420 @default.
- W2463488392 hasConcept C49039625 @default.
- W2463488392 hasConcept C51785407 @default.
- W2463488392 hasConcept C55493867 @default.
- W2463488392 hasConcept C57409179 @default.
- W2463488392 hasConcept C73588182 @default.
- W2463488392 hasConcept C86803240 @default.
- W2463488392 hasConcept C95444343 @default.
- W2463488392 hasConceptScore W2463488392C109316439 @default.
- W2463488392 hasConceptScore W2463488392C1491633281 @default.
- W2463488392 hasConceptScore W2463488392C175969161 @default.
- W2463488392 hasConceptScore W2463488392C181199279 @default.
- W2463488392 hasConceptScore W2463488392C202751555 @default.
- W2463488392 hasConceptScore W2463488392C203014093 @default.
- W2463488392 hasConceptScore W2463488392C2780216420 @default.
- W2463488392 hasConceptScore W2463488392C49039625 @default.
- W2463488392 hasConceptScore W2463488392C51785407 @default.
- W2463488392 hasConceptScore W2463488392C55493867 @default.
- W2463488392 hasConceptScore W2463488392C57409179 @default.
- W2463488392 hasConceptScore W2463488392C73588182 @default.
- W2463488392 hasConceptScore W2463488392C86803240 @default.
- W2463488392 hasConceptScore W2463488392C95444343 @default.
- W2463488392 hasIssue "4" @default.
- W2463488392 hasLocation W24634883921 @default.
- W2463488392 hasOpenAccess W2463488392 @default.
- W2463488392 hasPrimaryLocation W24634883921 @default.
- W2463488392 hasRelatedWork W112407786 @default.
- W2463488392 hasRelatedWork W2003442628 @default.
- W2463488392 hasRelatedWork W2086189475 @default.
- W2463488392 hasRelatedWork W2127296087 @default.
- W2463488392 hasRelatedWork W2463488392 @default.
- W2463488392 hasRelatedWork W2467933912 @default.
- W2463488392 hasRelatedWork W248869965 @default.
- W2463488392 hasRelatedWork W3165108474 @default.
- W2463488392 hasRelatedWork W3208917632 @default.
- W2463488392 hasRelatedWork W6902473 @default.
- W2463488392 hasVolume "288" @default.
- W2463488392 isParatext "false" @default.
- W2463488392 isRetracted "false" @default.
- W2463488392 magId "2463488392" @default.
- W2463488392 workType "article" @default.