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- W2463635552 abstract "Statins inhibit hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMCoAR), consequently suppressing cholesterol biosynthesis. Animal studies, epidemiologic studies, and clinical trials all support the low-density lipoprotein (LDL) hypothesis. The benefit of these statin drugs has greatly impacted treatment of cardiovascular diseases in primary and secondary prevention. Data from the results of Cholesterol Treatment Trialists’ (CTT) have proved that a reduction of 1 mmol/L in LDL cholesterol levels yields a consistent 23% reduction in the risk of major coronary events over 5 years. In addition, several clinical and basic science investigations have clearly demonstrated that statins may provide additional benefit besides LDL reduction. Statins exert a number of protective effects, including increasing nitric oxide bioavailability, improving endothelial function, stabilizing atherosclerotic plaque, reducing adhesion molecules (vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E-selectin), and decreasing circulating biomarkers of oxidative stress and inflammation, and inhibiting thrombogenic response, the so-called ‘pleiotropic effects’. 1)" @default.
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- W2463635552 date "2016-01-01" @default.
- W2463635552 modified "2023-09-26" @default.
- W2463635552 title "Pre-Treatment with Statins for Coronary Intervention: Pleiotropy of Statins or Effect of LDL-cholesterol Reduction?" @default.
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- W2463635552 doi "https://doi.org/10.4070/kcj.2016.46.4.468" @default.
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