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- W2463702457 abstract "Long-term nicotine use has been proposed as a risk-reduction strategy in smokers unwilling or unable to quit. However, its safety remains debated.Analysis of publications identified in PubMed, Toxibase, Google Scholar and in the Food and Drug Administration, and French National Authority for Health websites.Nicotine seems to be implicated in the genesis of atherosclerosis. It could be a cancer precursor, could be implicated in cancer proliferation and angiogenesis, in apoptosis reduction, and may be genotoxic. New studies are warranted for more complete assessment of the risk-benefit balance.It is difficult to affirm the safety of long term nicotine use. The risk-benefit balance should be assessed in terms of a risk-reduction strategy, as in other domains, notably illicit drug use." @default.
- W2463702457 created "2016-07-22" @default.
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- W2463702457 date "2016-12-01" @default.
- W2463702457 modified "2023-10-03" @default.
- W2463702457 title "Sécurité d’emploi de la nicotine au long cours : le débat n’est pas clos" @default.
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- W2463702457 doi "https://doi.org/10.1016/j.rmr.2016.05.002" @default.
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