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- W2463724811 abstract "Abstract: Peptide growth factor receptors on the surface of malignant cells bind to their ligands with high affinity, resulting in intracellular responses which cause differentiation, growth, and the survival of these cells. Peptide growth factors, or monoclonal antibodies (mAbs) which target growth factor receptors, have been conjugated to drugs, toxins, radionuclides, or other mAbs that recognize/activate effector cells which can phagocytose or kill. These types of conjugated products, whrch have the ability to kill malignant cells, we call bispecific molecules (BsMol) and is the basis of this review article. The growth factors/receptors covered include α- and β-melanocyte stimulating hormone (MSH), bombesin/gastrin releasing peptide (BN/GRP), epidermal growth factor (EGF), HER-2/neu oncogene protein (p185 HER2 ), interleukin-2, and somatostatin. The preparation and biological use/activity of the following BsMol are discussed: β-MSH-daunomycin, [Nie 4 ,D-Phe 7 ]MSH-anti-CD3, 111 In-DTPA-bis-α -MSH, DAB 389 -MSH, mAb22-Lys-BN, mAb22-Antag1, anti-EGFR/anti-CD3, DOXER2, DAB 389 EGF, 111 1n-DTPA-225, anti- p185 HER2 -SAP, 2B1, MDX-210, humAb4D5-8 x humAbUCHT1, DAB 486 1L-2, 111 1n-DTPA- octreotide (OctreoScan ® ), OX-26-NGF, and IVA039.1." @default.
- W2463724811 created "2016-07-22" @default.
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- W2463724811 date "1996-04-01" @default.
- W2463724811 modified "2023-10-18" @default.
- W2463724811 title "Targeting Growth Factor Receptors with Bispecific Molecules" @default.
- W2463724811 doi "https://doi.org/10.2174/092986730302220302093244" @default.
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