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- W2463742905 startingPage "e0158433" @default.
- W2463742905 abstract "MicroRNA (miRNA) may function as an oncogene or a tumor suppressor in tumorigenesis. However, the mechanism of miRNAs in adenoid cystic carcinoma (ACC) is unclear. Here, we provide evidence that miR-24-3p was downreglated and functions as a tumor suppressor in human lacrimal adenoid cystic carcinoma by suppressing proliferation and migration/invasion while promoting apoptosis. miR-24-3p down-regulated protein kinase C eta (PRKCH) by binding to its untranslated region (3’UTR). PRKCH increased the of the cell growth and migration/invasion in ACC cells and suppressed the expression of p53 and p21 in both mRNA and protein level. The overexpression of miR-24-3p decreased its malignant phenotype. Ectopic expression of PRKCH counteracted the suppression of malignancy induced by miR-24-3p, as well as ectopic expression of miR-24-3p rescued the suppression of PRKCH in the p53/p21 pathway. These results suggest that miR-24-3p promotes the p53/p21 pathway by down-regulating PRKCH expression in lacrimal adenoid cystic carcinoma cells." @default.
- W2463742905 created "2016-07-22" @default.
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- W2463742905 creator A5029714687 @default.
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- W2463742905 creator A5073501391 @default.
- W2463742905 date "2016-06-28" @default.
- W2463742905 modified "2023-09-23" @default.
- W2463742905 title "miR-24-3p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma by Targeting PRKCH to Regulate p53/p21 Pathway" @default.
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- W2463742905 doi "https://doi.org/10.1371/journal.pone.0158433" @default.
- W2463742905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4924841" @default.
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- W2463742905 hasPublicationYear "2016" @default.
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