Matches in SemOpenAlex for { <https://semopenalex.org/work/W2463761037> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2463761037 endingPage "9" @default.
- W2463761037 startingPage "53" @default.
- W2463761037 abstract "2-Palmitoyl[1,2,3,6,7,11b]hexahydro-4H-pyrazino[2-la]isoquinoline-4-one [III] a highly lipophilic analogue of the universal antihelminthic PRAZIQUANTEL [I] was rationally multi-stepwise synthesized and antischistosomally and biochemically screened. The 2-palmitoyl conjugation was hypothesized to be an antischistosomal adjuvant (Tween 40 mimicry), to the reported crucial pyrazino-isoquinoline moiety. On a constant weight doses bases of I and III (500 mg/kg mouse body weight), the activity of III was found to be approximately 70% of I (mice infected with S. mansoni cercariae) and with satisfactory toxicological and biochemical profile (mice liver and kidney functions). Equivalent molar weight assay (M 1:1.4 for I and III, respectively), which could further plead in favour of the potency of III, was not yet tested. The analogue III, which favourable incorporates the human metabolically and physiologically compatible, palmitic acid segment, seems to be an antischistosomally promising candidate for more integrated studies." @default.
- W2463761037 created "2016-07-22" @default.
- W2463761037 creator A5050309255 @default.
- W2463761037 creator A5072365505 @default.
- W2463761037 date "2000-06-10" @default.
- W2463761037 modified "2023-09-23" @default.
- W2463761037 title "Synthesis and study of the antischistosomal potency and induced biological parameters of a new 2-palmitoyl analogue of the universal antihelminthic praziquantel." @default.
- W2463761037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10846798" @default.
- W2463761037 hasPublicationYear "2000" @default.
- W2463761037 type Work @default.
- W2463761037 sameAs 2463761037 @default.
- W2463761037 citedByCount "4" @default.
- W2463761037 countsByYear W24637610372013 @default.
- W2463761037 countsByYear W24637610372014 @default.
- W2463761037 countsByYear W24637610372015 @default.
- W2463761037 crossrefType "journal-article" @default.
- W2463761037 hasAuthorship W2463761037A5050309255 @default.
- W2463761037 hasAuthorship W2463761037A5072365505 @default.
- W2463761037 hasConcept C165901193 @default.
- W2463761037 hasConcept C185592680 @default.
- W2463761037 hasConcept C202751555 @default.
- W2463761037 hasConcept C203014093 @default.
- W2463761037 hasConcept C2776225656 @default.
- W2463761037 hasConcept C2776568683 @default.
- W2463761037 hasConcept C2776923262 @default.
- W2463761037 hasConcept C2777863537 @default.
- W2463761037 hasConcept C2779744950 @default.
- W2463761037 hasConcept C55493867 @default.
- W2463761037 hasConcept C57992300 @default.
- W2463761037 hasConcept C71240020 @default.
- W2463761037 hasConcept C86803240 @default.
- W2463761037 hasConcept C98274493 @default.
- W2463761037 hasConceptScore W2463761037C165901193 @default.
- W2463761037 hasConceptScore W2463761037C185592680 @default.
- W2463761037 hasConceptScore W2463761037C202751555 @default.
- W2463761037 hasConceptScore W2463761037C203014093 @default.
- W2463761037 hasConceptScore W2463761037C2776225656 @default.
- W2463761037 hasConceptScore W2463761037C2776568683 @default.
- W2463761037 hasConceptScore W2463761037C2776923262 @default.
- W2463761037 hasConceptScore W2463761037C2777863537 @default.
- W2463761037 hasConceptScore W2463761037C2779744950 @default.
- W2463761037 hasConceptScore W2463761037C55493867 @default.
- W2463761037 hasConceptScore W2463761037C57992300 @default.
- W2463761037 hasConceptScore W2463761037C71240020 @default.
- W2463761037 hasConceptScore W2463761037C86803240 @default.
- W2463761037 hasConceptScore W2463761037C98274493 @default.
- W2463761037 hasIssue "1" @default.
- W2463761037 hasLocation W24637610371 @default.
- W2463761037 hasOpenAccess W2463761037 @default.
- W2463761037 hasPrimaryLocation W24637610371 @default.
- W2463761037 hasRelatedWork W2003418191 @default.
- W2463761037 hasRelatedWork W2025395214 @default.
- W2463761037 hasRelatedWork W2036447795 @default.
- W2463761037 hasRelatedWork W2038588110 @default.
- W2463761037 hasRelatedWork W2049606241 @default.
- W2463761037 hasRelatedWork W2070588828 @default.
- W2463761037 hasRelatedWork W2759870718 @default.
- W2463761037 hasRelatedWork W2953250661 @default.
- W2463761037 hasRelatedWork W4240443993 @default.
- W2463761037 hasRelatedWork W4281686289 @default.
- W2463761037 hasVolume "57" @default.
- W2463761037 isParatext "false" @default.
- W2463761037 isRetracted "false" @default.
- W2463761037 magId "2463761037" @default.
- W2463761037 workType "article" @default.