Matches in SemOpenAlex for { <https://semopenalex.org/work/W2463792207> ?p ?o ?g. }
- W2463792207 endingPage "e1204504" @default.
- W2463792207 startingPage "e1204504" @default.
- W2463792207 abstract "Despite recent advances in immunotherapy of renal cell carcinoma (RCC), peptide vaccination strategies still lack an approach for personalized peptide vaccination that takes intra- and inter-tumoral heterogeneity and biological characteristics into account. In this study, we use an immunoprecipitation and mass spectrometry-based approach supplemented by network analysis of HLA ligands to target this goal. By analyzing HLA-presented peptides for HLA class I and II of 11 malignant and 6 non-malignant kidney tissue samples, more than 2,700 peptides and 1,600 corresponding source proteins were identified. A high overlap with HLA ligands derived from peripheral blood mononuclear cells (PBMCs) was detected most likely due to tumor-infiltrating inflammatory cells and therefore excluded from network analysis. Subsequent biological function analysis of HLA ligands by the GeneMANIA online platform showed enrichment for well established, but also novel, pathways and biological processes involved in carcinogenesis of RCC almost exclusively in malignant tissue samples. By exploring source proteins involved in these overrepresented pathways, we verified various known tumor-associated antigens (TAAs) for RCC (e.g., CA9, EGLN3, IGFBP3, MMP7, PAX2, VEGFA, or EGFR) but could also detect novel TAAs for RCC (e.g., PLOD2, LOX, ENPEP, or TGFBI). Some of these new TAAs had already been shown to elicit a T cell response in cancer patients. Thus, network analysis of HLA ligands provided a new platform for implementing personalized, multipeptide vaccines with potentially synergistic antitumor effects." @default.
- W2463792207 created "2016-07-22" @default.
- W2463792207 creator A5010250023 @default.
- W2463792207 creator A5012626247 @default.
- W2463792207 creator A5021416004 @default.
- W2463792207 creator A5034310234 @default.
- W2463792207 creator A5061721767 @default.
- W2463792207 creator A5088860072 @default.
- W2463792207 creator A5090087637 @default.
- W2463792207 creator A5090153362 @default.
- W2463792207 date "2016-06-30" @default.
- W2463792207 modified "2023-10-16" @default.
- W2463792207 title "Carcinogenesis of renal cell carcinoma reflected in HLA ligands: A novel approach for synergistic peptide vaccination design" @default.
- W2463792207 cites W1529568247 @default.
- W2463792207 cites W1548175823 @default.
- W2463792207 cites W1605757623 @default.
- W2463792207 cites W1673643619 @default.
- W2463792207 cites W1749022239 @default.
- W2463792207 cites W1812160849 @default.
- W2463792207 cites W1848050571 @default.
- W2463792207 cites W1964039431 @default.
- W2463792207 cites W1964312509 @default.
- W2463792207 cites W1965437294 @default.
- W2463792207 cites W1967068357 @default.
- W2463792207 cites W1971302107 @default.
- W2463792207 cites W1973402890 @default.
- W2463792207 cites W1973980688 @default.
- W2463792207 cites W1982488143 @default.
- W2463792207 cites W1985213868 @default.
- W2463792207 cites W1995168398 @default.
- W2463792207 cites W1998307950 @default.
- W2463792207 cites W1998728654 @default.
- W2463792207 cites W1999966467 @default.
- W2463792207 cites W2013020286 @default.
- W2463792207 cites W2018288777 @default.
- W2463792207 cites W2028415685 @default.
- W2463792207 cites W2033326553 @default.
- W2463792207 cites W2033363278 @default.
- W2463792207 cites W2038440293 @default.
- W2463792207 cites W2040584152 @default.
- W2463792207 cites W2050181929 @default.
- W2463792207 cites W2050428476 @default.
- W2463792207 cites W2053943711 @default.
- W2463792207 cites W2060260809 @default.
- W2463792207 cites W2064625349 @default.
- W2463792207 cites W2079018735 @default.
- W2463792207 cites W2080073026 @default.
- W2463792207 cites W2082830752 @default.
- W2463792207 cites W2090852455 @default.
- W2463792207 cites W2095299473 @default.
- W2463792207 cites W2095927984 @default.
- W2463792207 cites W2101858690 @default.
- W2463792207 cites W2102367710 @default.
- W2463792207 cites W2113950502 @default.
- W2463792207 cites W2117796375 @default.
- W2463792207 cites W2119629056 @default.
- W2463792207 cites W2120953129 @default.
- W2463792207 cites W2125112000 @default.
- W2463792207 cites W2139593382 @default.
- W2463792207 cites W2143163879 @default.
- W2463792207 cites W2149456801 @default.
- W2463792207 cites W2151856174 @default.
- W2463792207 cites W2154707187 @default.
- W2463792207 cites W2161682775 @default.
- W2463792207 cites W2165431330 @default.
- W2463792207 cites W2334668438 @default.
- W2463792207 cites W2335012284 @default.
- W2463792207 cites W2336280922 @default.
- W2463792207 cites W2336374639 @default.
- W2463792207 cites W2345120190 @default.
- W2463792207 cites W4312036571 @default.
- W2463792207 doi "https://doi.org/10.1080/2162402x.2016.1204504" @default.
- W2463792207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5007970" @default.
- W2463792207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27622074" @default.
- W2463792207 hasPublicationYear "2016" @default.
- W2463792207 type Work @default.
- W2463792207 sameAs 2463792207 @default.
- W2463792207 citedByCount "19" @default.
- W2463792207 countsByYear W24637922072017 @default.
- W2463792207 countsByYear W24637922072018 @default.
- W2463792207 countsByYear W24637922072019 @default.
- W2463792207 countsByYear W24637922072020 @default.
- W2463792207 countsByYear W24637922072021 @default.
- W2463792207 countsByYear W24637922072022 @default.
- W2463792207 countsByYear W24637922072023 @default.
- W2463792207 crossrefType "journal-article" @default.
- W2463792207 hasAuthorship W2463792207A5010250023 @default.
- W2463792207 hasAuthorship W2463792207A5012626247 @default.
- W2463792207 hasAuthorship W2463792207A5021416004 @default.
- W2463792207 hasAuthorship W2463792207A5034310234 @default.
- W2463792207 hasAuthorship W2463792207A5061721767 @default.
- W2463792207 hasAuthorship W2463792207A5088860072 @default.
- W2463792207 hasAuthorship W2463792207A5090087637 @default.
- W2463792207 hasAuthorship W2463792207A5090153362 @default.
- W2463792207 hasBestOaLocation W24637922071 @default.
- W2463792207 hasConcept C104397665 @default.
- W2463792207 hasConcept C121608353 @default.
- W2463792207 hasConcept C137061746 @default.