FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2463822671> ?p ?o ?g. }

• W2463822671 endingPage "1432" @default.
• W2463822671 startingPage "1419" @default.
• W2463822671 abstract "The loss of synaptic structure and function has been linked to the cognitive impairment of Alzheimer's disease (AD). Dysregulation of the actin cytoskeleton, which plays a key role in regulating the integrity of synapses and the transport of synaptic proteins, has been suggested to contribute to the pathology of AD. In this study, we found that glutamate receptor surface expression and synaptic function in frontal cortical neurons were significant diminished in a familial AD (FAD) model, which was correlated with the reduction of phosphorylated cofilin, a key protein regulating the dynamics of actin filaments. Injecting a cofilin dephosphorylation inhibitory peptide to FAD mice led to the partial rescue of the surface expression of AMPA and NMDA receptor subunits, as well as the partial restoration of AMPAR- and NMDAR-mediated synaptic currents. Moreover, the impaired working memory and novel object recognition memory in FAD mice were partially ameliorated by injections of the cofilin dephosphorylation inhibitory peptide. These results suggest that targeting the cofilin-actin signaling holds promise to mitigate the physiological and behavioral abnormality in AD." @default.
• W2463822671 created "2016-07-22" @default.
• W2463822671 creator A5015860750 @default.
• W2463822671 creator A5021915616 @default.
• W2463822671 creator A5029257310 @default.
• W2463822671 creator A5036408954 @default.
• W2463822671 creator A5041579490 @default.
• W2463822671 creator A5075408897 @default.
• W2463822671 creator A5076452990 @default.
• W2463822671 creator A5078901632 @default.
• W2463822671 creator A5079705999 @default.
• W2463822671 date "2016-08-08" @default.
• W2463822671 modified "2023-10-16" @default.
• W2463822671 title "Partial Amelioration of Synaptic and Cognitive Deficits by Inhibiting Cofilin Dephosphorylation in an Animal Model of Alzheimer’s Disease" @default.
• W2463822671 cites W1519306389 @default.
• W2463822671 cites W1569092853 @default.
• W2463822671 cites W1573728483 @default.
• W2463822671 cites W1580790875 @default.
• W2463822671 cites W1589135618 @default.
• W2463822671 cites W1591312627 @default.
• W2463822671 cites W1967117930 @default.
• W2463822671 cites W1967678083 @default.
• W2463822671 cites W1968674432 @default.
• W2463822671 cites W1972764647 @default.
• W2463822671 cites W1979730343 @default.
• W2463822671 cites W1984559046 @default.
• W2463822671 cites W1984924722 @default.
• W2463822671 cites W1985086842 @default.
• W2463822671 cites W1986542309 @default.
• W2463822671 cites W1986782185 @default.
• W2463822671 cites W1990752558 @default.
• W2463822671 cites W1992321756 @default.
• W2463822671 cites W1992888364 @default.
• W2463822671 cites W1993217787 @default.
• W2463822671 cites W2002235740 @default.
• W2463822671 cites W2003436719 @default.
• W2463822671 cites W2003736664 @default.
• W2463822671 cites W2006472192 @default.
• W2463822671 cites W2009511852 @default.
• W2463822671 cites W2020081859 @default.
• W2463822671 cites W2024469079 @default.
• W2463822671 cites W2027646146 @default.
• W2463822671 cites W2031429450 @default.
• W2463822671 cites W2031534534 @default.
• W2463822671 cites W2033145714 @default.
• W2463822671 cites W2038809411 @default.
• W2463822671 cites W2040653138 @default.
• W2463822671 cites W2041794412 @default.
• W2463822671 cites W2045491381 @default.
• W2463822671 cites W2054366304 @default.
• W2463822671 cites W2061387301 @default.
• W2463822671 cites W2068011527 @default.
• W2463822671 cites W2068212050 @default.
• W2463822671 cites W2070005343 @default.
• W2463822671 cites W2070976880 @default.
• W2463822671 cites W2072441360 @default.
• W2463822671 cites W2075496760 @default.
• W2463822671 cites W2078247521 @default.
• W2463822671 cites W2090677095 @default.
• W2463822671 cites W2114459079 @default.
• W2463822671 cites W2126496496 @default.
• W2463822671 cites W2128300032 @default.
• W2463822671 cites W2132485762 @default.
• W2463822671 cites W2144529104 @default.
• W2463822671 cites W2144703014 @default.
• W2463822671 cites W2145144183 @default.
• W2463822671 cites W2152722274 @default.
• W2463822671 cites W2159807079 @default.
• W2463822671 cites W2160038308 @default.
• W2463822671 cites W2164510688 @default.
• W2463822671 cites W2164670684 @default.
• W2463822671 cites W2168025729 @default.
• W2463822671 cites W2170644095 @default.
• W2463822671 cites W2171776741 @default.
• W2463822671 cites W600197995 @default.
• W2463822671 doi "https://doi.org/10.3233/jad-160167" @default.
• W2463822671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27372643" @default.
• W2463822671 hasPublicationYear "2016" @default.
• W2463822671 type Work @default.
• W2463822671 sameAs 2463822671 @default.
• W2463822671 citedByCount "24" @default.
• W2463822671 countsByYear W24638226712017 @default.
• W2463822671 countsByYear W24638226712018 @default.
• W2463822671 countsByYear W24638226712019 @default.
• W2463822671 countsByYear W24638226712020 @default.
• W2463822671 countsByYear W24638226712021 @default.
• W2463822671 countsByYear W24638226712022 @default.
• W2463822671 countsByYear W24638226712023 @default.
• W2463822671 crossrefType "journal-article" @default.
• W2463822671 hasAuthorship W2463822671A5015860750 @default.
• W2463822671 hasAuthorship W2463822671A5021915616 @default.
• W2463822671 hasAuthorship W2463822671A5029257310 @default.
• W2463822671 hasAuthorship W2463822671A5036408954 @default.
• W2463822671 hasAuthorship W2463822671A5041579490 @default.
• W2463822671 hasAuthorship W2463822671A5075408897 @default.
• W2463822671 hasAuthorship W2463822671A5076452990 @default.
• W2463822671 hasAuthorship W2463822671A5078901632 @default.
• W2463822671 hasAuthorship W2463822671A5079705999 @default.

• next