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- W2463958404 abstract "to the editor: Edwards et al. (June 17 issue) 1 show that the anti-CD20 monoclonal antibody rituximab provides effective therapy for rheumatoid arthritis. They report that the effects of rituximab are not associated with changes in serum immunoglobulin levels, suggesting that this anti-CD20 antibody alleviates symptoms associated with rheumatoid arthritis through an antibody-independent mechanism. In their study, serious bacterial infections occurred in only four patients (3.3 percent) in the rituximab groups. Nevertheless, we suspect that the use of this therapeutic protein may lead to severe infectious diseases such as tuberculosis, sepsis, and viremia. The target of rituximab, CD20, has been reported to associate with major-histocompatibilitycomplex (MHC) class II molecules and to have an important role in the activation of B cells. 2 Consequently, anti-antigen presentation may be one of the antibody-independent mechanisms by which rituximab functions. If this is the case, clinicians should be aware that the use of rituximab could allow for the development of severe infections, especially in cases in which functions of antigen presentation play an important role in disease protection." @default.
- W2463958404 created "2016-07-22" @default.
- W2463958404 date "2004-10-28" @default.
- W2463958404 modified "2023-09-27" @default.
- W2463958404 title "Rituximab for Rheumatoid Arthritis" @default.
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- W2463958404 doi "https://doi.org/10.1056/nejm200410283511820" @default.
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