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• W2463965661 endingPage "355" @default.
• W2463965661 startingPage "343" @default.
• W2463965661 abstract "Dirofilaria immitis, a filarial parasite, causes cardiopulmonary dirofilariasis in dogs, cats and wild canids. The macrocyclic lactone (ML) class of drugs has been used to prevent heartworm infection. There is confirmed ML resistance in D. immitis and thus there is an urgent need to find new anthelmintics that could prevent and/or control the disease. Targeting ion channels of D. immitis for drug design has obvious advantages. These channels, present in the nematode nervous system, control movement, feeding, mating and respond to environmental cues which are necessary for survival of the parasite. Any new drug that targets these ion channels is likely to have a motility phenotype and should act to clear the worms from the host. Many of the successful anthelmintics in the past have targeted these ion channels and receptors. Knowledge about genetic variability of the ion channel and receptor genes should be useful information for drug design as receptor polymorphism may affect responses to a drug. Such information may also be useful for anticipation of possible resistance development. A total of 224 ion channel genes/subunits have been identified in the genome of D. immitis. Whole genome sequencing data of parasites from eight different geographical locations, four from ML-susceptible populations and the other four from ML-loss of efficacy (LOE) populations, were used for polymorphism analysis. We identified 1762 single nucleotide polymorphic (SNP) sites (1508 intronic and 126 exonic) in these 224 ion channel genes/subunits with an overall polymorphic rate of 0.18%. Of the SNPs found in the exon regions, 129 of them caused a non-synonymous type of polymorphism. Fourteen of the exonic SNPs caused a change in predicted secondary structure. A few of the SNPs identified may have an effect on gene expression, function of the protein and resistance selection processes." @default.
• W2463965661 created "2016-07-22" @default.
• W2463965661 creator A5017952304 @default.
• W2463965661 creator A5028668734 @default.
• W2463965661 creator A5029497455 @default.
• W2463965661 creator A5072569466 @default.
• W2463965661 creator A5073368410 @default.
• W2463965661 creator A5081842118 @default.
• W2463965661 date "2016-12-01" @default.
• W2463965661 modified "2023-10-16" @default.
• W2463965661 title "Polymorphism in ion channel genes of Dirofilaria immitis : Relevant knowledge for future anthelmintic drug design" @default.
• W2463965661 cites W1484347389 @default.
• W2463965661 cites W1504724494 @default.
• W2463965661 cites W1569358416 @default.
• W2463965661 cites W160231570 @default.
• W2463965661 cites W1605667399 @default.
• W2463965661 cites W1947875388 @default.
• W2463965661 cites W1966605560 @default.
• W2463965661 cites W1966685657 @default.
• W2463965661 cites W1967285730 @default.
• W2463965661 cites W1968208599 @default.
• W2463965661 cites W1969457282 @default.
• W2463965661 cites W1971179225 @default.
• W2463965661 cites W1971446667 @default.
• W2463965661 cites W1973722820 @default.
• W2463965661 cites W1974398081 @default.
• W2463965661 cites W1975676315 @default.
• W2463965661 cites W1975972945 @default.
• W2463965661 cites W1978294750 @default.
• W2463965661 cites W1983815517 @default.
• W2463965661 cites W1984081494 @default.
• W2463965661 cites W1988963904 @default.
• W2463965661 cites W1993617925 @default.
• W2463965661 cites W1993999630 @default.
• W2463965661 cites W2000755750 @default.
• W2463965661 cites W2002861734 @default.
• W2463965661 cites W2003446114 @default.
• W2463965661 cites W2004113088 @default.
• W2463965661 cites W2009748599 @default.
• W2463965661 cites W2009996427 @default.
• W2463965661 cites W2011671647 @default.
• W2463965661 cites W2015519080 @default.
• W2463965661 cites W2015901891 @default.
• W2463965661 cites W2018753422 @default.
• W2463965661 cites W2019454741 @default.
• W2463965661 cites W2019539444 @default.
• W2463965661 cites W2020089365 @default.
• W2463965661 cites W2022230059 @default.
• W2463965661 cites W2022584229 @default.
• W2463965661 cites W2025142458 @default.
• W2463965661 cites W2025814595 @default.
• W2463965661 cites W2028247649 @default.
• W2463965661 cites W2028585273 @default.
• W2463965661 cites W2031645051 @default.
• W2463965661 cites W2032855201 @default.
• W2463965661 cites W2034337979 @default.
• W2463965661 cites W2037077087 @default.
• W2463965661 cites W2037865308 @default.
• W2463965661 cites W2038492783 @default.
• W2463965661 cites W2038638853 @default.
• W2463965661 cites W2043575878 @default.
• W2463965661 cites W2046050698 @default.
• W2463965661 cites W2046643103 @default.
• W2463965661 cites W2049595315 @default.
• W2463965661 cites W2051712077 @default.
• W2463965661 cites W2052109803 @default.
• W2463965661 cites W2052251235 @default.
• W2463965661 cites W2056528158 @default.
• W2463965661 cites W2056970473 @default.
• W2463965661 cites W2058860498 @default.
• W2463965661 cites W2058864686 @default.
• W2463965661 cites W2060396426 @default.
• W2463965661 cites W2061878700 @default.
• W2463965661 cites W2063318299 @default.
• W2463965661 cites W2065606887 @default.
• W2463965661 cites W2066923327 @default.
• W2463965661 cites W2077740759 @default.
• W2463965661 cites W2080136671 @default.
• W2463965661 cites W2080228333 @default.
• W2463965661 cites W2081737180 @default.
• W2463965661 cites W2089980375 @default.
• W2463965661 cites W2090047302 @default.
• W2463965661 cites W2090402915 @default.
• W2463965661 cites W2092329175 @default.
• W2463965661 cites W2093615671 @default.
• W2463965661 cites W2097847337 @default.
• W2463965661 cites W2105503585 @default.
• W2463965661 cites W2107470469 @default.
• W2463965661 cites W2107484490 @default.
• W2463965661 cites W2114750701 @default.
• W2463965661 cites W2115726385 @default.
• W2463965661 cites W2125829193 @default.
• W2463965661 cites W2127890421 @default.
• W2463965661 cites W2129062902 @default.
• W2463965661 cites W2130571887 @default.
• W2463965661 cites W2132800912 @default.
• W2463965661 cites W2139062153 @default.
• W2463965661 cites W2145037154 @default.

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