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• W2464300964 abstract "Abstract In addition to antiplatelet autoantibodies, CD8 + cytotoxic T lymphocytes (CTLs) play an important role in the increased platelet destruction in immune thrombocytopenia (ITP). Recent studies have highlighted that platelet desialylation leads to platelet clearance via hepatocyte asialoglycoprotein receptors (ASGPRs). Whether CD8 + T cells induce platelet desialylation in ITP remains unclear. Here, we investigated the cytotoxicity of CD8 + T cells towards platelets and platelet desialylation in ITP. We found that the desialylation of fresh platelets was significantly higher in ITP patients with positive cytotoxicity of CD8 + T cells than those without cytotoxicity and controls. In vitro , CD8 + T cells from ITP patients with positive cytotoxicity induced significant platelet desialylation, neuraminidase-1 expression on the platelet surface, and platelet phagocytosis by hepatocytes. To study platelet survival and clearance in vivo , CD61 knockout mice were immunized and their CD8 + splenocytes were used. Platelets co-cultured with these CD8 + splenocytes demonstrated decreased survival in the circulation and increased phagocytosis in the liver. Both neuraminidase inhibitor and ASGPRs competitor significantly improved platelet survival and abrogated platelet clearance caused by CD8 + splenocytes. These findings suggest that CD8 + T cells induce platelet desialylation and platelet clearance in the liver in ITP, which may be a novel mechanism of ITP." @default.
• W2464300964 created "2016-07-22" @default.
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• W2464300964 date "2016-06-20" @default.
• W2464300964 modified "2023-10-13" @default.
• W2464300964 title "CD8+ T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia" @default.
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• W2464300964 doi "https://doi.org/10.1038/srep27445" @default.
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