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- W2464492583 abstract "Purpose:To develop a volume-independent metric called the Gaussian Weighted Conformity Index (GWCI) for assessing conformality of stereotactic radiosurgery plans for small brain tumors.Methods:The GWCI calculates bi-directional distance by searching for corresponding points between the prescription isodose line and tumor contour, assigning different scoring weights to tumor coverage with a score of 1.0 being ideal assuming an idealized Gaussian distribution of dose around the tumor. (Figure 1, left) The GWCI penalizes tumor under-dosing three times more heavily than the prescription isodose falling outside the tumor. (Figure 1, middle) A user interface was created to calculate GWCI from images and RT structures (Figure 1, right). Patients receiving radiosurgery were randomly selected and images and RT structures were exported to MiM (MiMVista, Cleveland, OH) to calculate traditional conformality indices (CI). CIs were calculated for 39 tumors from patients receiving Gamma Knife radiosurgery (GKSRS) and from 10 tumors from patients receiving linac-based stereotactic radiosurgery (L-SRS). GWCIs were calculated for 14 tumors from patients receiving GKSRS and for 10 tumors from patients receiving L-SRS.Results:Conformality indices calculated from 39 GKSRS plans and 10 L-SRS plans are plotted in Figure 2 demonstrating that as tumour volume gets smaller, conformality index increases. GWCIs for 14 tumors were plotted against CIs and linear regression was performed (Figure 3) yielding GWCI = −.077*CI + 1.044 (R2 = .52). Utilizing this regression, the corresponding GWCI to a traditionally-acceptable CI of 1.5 was calculated as 0.927.Conclusion:Limitations of current conformity metrics become apparent when applied to radiosurgery treatment plans. A GWCI tool was successfully developed which can be used to accurately score the quality of an individual treatment plan while eliminating small volume effects. A GWCI of 0.93 may be used as a volume-independent cutoff for plan conformality." @default.
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- W2464492583 date "2016-06-01" @default.
- W2464492583 modified "2023-09-27" @default.
- W2464492583 title "SU-F-T-599: Volume-Independent Conformity Index for Stereotactic Brain Tumors" @default.
- W2464492583 doi "https://doi.org/10.1118/1.4956784" @default.
- W2464492583 hasPublicationYear "2016" @default.
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