Matches in SemOpenAlex for { <https://semopenalex.org/work/W2464518668> ?p ?o ?g. }
- W2464518668 endingPage "1051" @default.
- W2464518668 startingPage "1036" @default.
- W2464518668 abstract "Abstract Chromosomal aberrations and multiple genome-wide association studies (GWAS) have established a major hematopoietic quantitative trait locus in chromosome 6q23.3. The locus comprises an active enhancer region, in which some of the associated SNPs alter transcription factor binding. We now identify miR-3662 as a new functional driver contributing to the associated phenotypes. The GWAS SNPs are strongly associated with higher miR-3662 expression. Genome editing of rs66650371, a three-base-pair deletion, suggests a functional link between the SNP genotype and the abundance of miR-3662. Increasing miR-3662′s abundance increases colony formation in hematopoietic progenitor cells, particularly the erythroid lineage. In contrast, miR-3662 is not expressed in acute myeloid leukemia cells, and its overexpression has potent antileukemic effects in vitro and in vivo. Mechanistically, miR-3662 directly targets NF-κB–mediated transcription. Thus, miR-3662 is a new player of the hematopoietic 6q23.3 locus. Significance: The characterization of miR-3662 has identified a new actor in the prominent hematopoietic quantitative trait locus in chromosome 6q23.3. The mechanistic insights into miR-3662′s function may reveal novel or only partially known pathways for normal and malignant hematopoietic cell proliferation. Cancer Discov; 6(9); 1036–51. ©2016 AACR. This article is highlighted in the In This Issue feature, p. 932" @default.
- W2464518668 created "2016-07-22" @default.
- W2464518668 creator A5015187893 @default.
- W2464518668 creator A5031915047 @default.
- W2464518668 creator A5045110664 @default.
- W2464518668 creator A5049153574 @default.
- W2464518668 creator A5049387340 @default.
- W2464518668 creator A5056314507 @default.
- W2464518668 creator A5062108544 @default.
- W2464518668 creator A5063107866 @default.
- W2464518668 creator A5063189075 @default.
- W2464518668 creator A5072361065 @default.
- W2464518668 creator A5072858554 @default.
- W2464518668 creator A5080781659 @default.
- W2464518668 creator A5081261541 @default.
- W2464518668 creator A5082878312 @default.
- W2464518668 creator A5086647663 @default.
- W2464518668 creator A5088452270 @default.
- W2464518668 date "2016-08-31" @default.
- W2464518668 modified "2023-10-17" @default.
- W2464518668 title "Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia" @default.
- W2464518668 cites W1255676896 @default.
- W2464518668 cites W1504924831 @default.
- W2464518668 cites W1832829702 @default.
- W2464518668 cites W1965975157 @default.
- W2464518668 cites W1966870938 @default.
- W2464518668 cites W1968110789 @default.
- W2464518668 cites W1968630647 @default.
- W2464518668 cites W1971476169 @default.
- W2464518668 cites W1973082669 @default.
- W2464518668 cites W1977904234 @default.
- W2464518668 cites W1979421770 @default.
- W2464518668 cites W1982312323 @default.
- W2464518668 cites W1995997313 @default.
- W2464518668 cites W2000577183 @default.
- W2464518668 cites W201163751 @default.
- W2464518668 cites W2012020901 @default.
- W2464518668 cites W2019602338 @default.
- W2464518668 cites W2021708309 @default.
- W2464518668 cites W2049959719 @default.
- W2464518668 cites W2050855482 @default.
- W2464518668 cites W2051669225 @default.
- W2464518668 cites W2053870274 @default.
- W2464518668 cites W2066725248 @default.
- W2464518668 cites W2067362158 @default.
- W2464518668 cites W2073564321 @default.
- W2464518668 cites W2076426515 @default.
- W2464518668 cites W2077387286 @default.
- W2464518668 cites W2091854066 @default.
- W2464518668 cites W2099667634 @default.
- W2464518668 cites W2104115143 @default.
- W2464518668 cites W2104427970 @default.
- W2464518668 cites W2107256939 @default.
- W2464518668 cites W2122288142 @default.
- W2464518668 cites W2127962225 @default.
- W2464518668 cites W2134887638 @default.
- W2464518668 cites W2139826725 @default.
- W2464518668 cites W2143417044 @default.
- W2464518668 cites W2145051141 @default.
- W2464518668 cites W2153657879 @default.
- W2464518668 cites W2153926593 @default.
- W2464518668 cites W2155766871 @default.
- W2464518668 cites W2162279004 @default.
- W2464518668 cites W2429878409 @default.
- W2464518668 doi "https://doi.org/10.1158/2159-8290.cd-16-0023" @default.
- W2464518668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5168803" @default.
- W2464518668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27354268" @default.
- W2464518668 hasPublicationYear "2016" @default.
- W2464518668 type Work @default.
- W2464518668 sameAs 2464518668 @default.
- W2464518668 citedByCount "14" @default.
- W2464518668 countsByYear W24645186682017 @default.
- W2464518668 countsByYear W24645186682018 @default.
- W2464518668 countsByYear W24645186682019 @default.
- W2464518668 countsByYear W24645186682020 @default.
- W2464518668 countsByYear W24645186682021 @default.
- W2464518668 countsByYear W24645186682023 @default.
- W2464518668 crossrefType "journal-article" @default.
- W2464518668 hasAuthorship W2464518668A5015187893 @default.
- W2464518668 hasAuthorship W2464518668A5031915047 @default.
- W2464518668 hasAuthorship W2464518668A5045110664 @default.
- W2464518668 hasAuthorship W2464518668A5049153574 @default.
- W2464518668 hasAuthorship W2464518668A5049387340 @default.
- W2464518668 hasAuthorship W2464518668A5056314507 @default.
- W2464518668 hasAuthorship W2464518668A5062108544 @default.
- W2464518668 hasAuthorship W2464518668A5063107866 @default.
- W2464518668 hasAuthorship W2464518668A5063189075 @default.
- W2464518668 hasAuthorship W2464518668A5072361065 @default.
- W2464518668 hasAuthorship W2464518668A5072858554 @default.
- W2464518668 hasAuthorship W2464518668A5080781659 @default.
- W2464518668 hasAuthorship W2464518668A5081261541 @default.
- W2464518668 hasAuthorship W2464518668A5082878312 @default.
- W2464518668 hasAuthorship W2464518668A5086647663 @default.
- W2464518668 hasAuthorship W2464518668A5088452270 @default.
- W2464518668 hasBestOaLocation W24645186681 @default.
- W2464518668 hasConcept C104317684 @default.
- W2464518668 hasConcept C106208931 @default.
- W2464518668 hasConcept C109159458 @default.