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• W2464602309 startingPage "1893" @default.
• W2464602309 abstract "The terpenoids constitute one of the largest and most diverse classes of natural compounds with applications as pharmaceuticals, flavorings and fragrances, pesticides and biofuels. Synthetic biology is ideally placed to create new routes to this chemical diversity and facilitation of new compound discovery. The C10 monoterpenoids display a huge structural diversity produced from a single substrate, geranyl diphosphate, by a family of monoterpene cyclases and synthases (mTC/S). Here we employ a library of mTC/S in a single 'plug and play' platform system for the production of over 30 different monoterpenoids in Escherichia coli by fermentation on glucose. These products include several compounds never before produced in engineered microbes demonstrating the power of this approach to rapidly create routes to structural diversity." @default.
• W2464602309 created "2016-07-22" @default.
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• W2464602309 date "2016-06-16" @default.
• W2464602309 modified "2023-10-14" @default.
• W2464602309 title "A ‘Plug and Play’ Platform for the Production of Diverse Monoterpene Hydrocarbon Scaffolds in<i>Escherichia coli</i>." @default.
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• W2464602309 doi "https://doi.org/10.1002/slct.201600563" @default.
• W2464602309 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5947754" @default.
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