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- W2464780309 abstract "Cholinesterase inhibitors (ChEI) presently in clinical trials for the treatment of Alzheimer’s disease (AD) in Japan, USA and Europe include more than a dozen drugs, most of which have already advanced to clinical phase III and two (tacrine and donepezil) are registered in the USA and Europe (Giacobini, 1996). It is likely that in the next two-year period (1997–1999) at least three other ChEI will be registered world wide. The second generation of ChEI, in order to replace tacrine, will have to fulfill specific requirements (Giacobini, 1996). After analyzing the results emerging from clinical trials, the first question to be answered is: do ChEI work in the AD patient, and if so, how do they work? A second question is: are there major differences among various compounds with regard to efficacy, percentage of treatable patients and side effects? These two fundamental questions can be partially answered by comparing recent clinical data (Table 1)." @default.
- W2464780309 created "2016-07-22" @default.
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- W2464780309 date "1998-01-01" @default.
- W2464780309 modified "2023-09-23" @default.
- W2464780309 title "Cholinesterase Inhibitors for Alzheimer’s Disease Therapy" @default.
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- W2464780309 doi "https://doi.org/10.1007/978-1-4615-5337-3_81" @default.
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