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- W2464847135 abstract "A group of 2968 patients under 50 and on oral contraception was observed with the purpose of detecting as early as possible any carcinogenetic effects. 2349 women were on combined OCs 137 on sequental OCs and 482 on progestational OCs namely lynestrenol and medroxyprogesterone. Cytological studies of the cervical smears from the 3 groups of patients revealed that progestational contraception and especially medroxyprogesterone had a protective effect against eventual metaplasic lesions. It was also found that treatment with progesterone resulted in complete regression of endometrial adenomatous hyperplasia. In the treatment of adeno-carcinoma a silastic applicator impregnated with medroxyprogesterone was used instead of curietherapy resulting in the destruction of cancerous tissues in 60% of cases. Weekly administration of medroxyprogesterone was thought capable of reducing to zero the rate of recidivity. For these reasons contraception with medroxyprogesterone seems to be much indicated for menopausal women since at the same time it protects against endometrial hyperplasia." @default.
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- W2464847135 date "1978-01-01" @default.
- W2464847135 modified "2023-09-23" @default.
- W2464847135 title "[Beneficial effects of contraceptive doses and large doses of medroxyprogesterone in the prevention and treatment of uterine hyperplasia]." @default.
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