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• W2464961363 abstract "Zika viral infection is caused by an emerging mosquito borne virus the Zika virus ZIKV and threatens to become a global pandemic While not life threatening the Zika Virus Disease ZVD is suspected to be associated with severe neurological disorders including Guillain Barr eacute syndrome and microcephaly Currently no known cure or diagnostic tests for ZVD are available The host cell molecular targets are unknown for ZIKV The ZIKV is related to various other mosquito borne viruses including the Chikungunya Dengue Japanese encephalitis Spondweni Yellow fever and West Nile viruses The host cell targets are known for most of these viruses All of these viruses harbor common protein motifs and domains raising the possibility of shared molecular targets in the host genome To facilitate target s discovery for the ZIKV therapy the disease and protein knowledge databases were datamined for Zika related viruses An initial database of genes was established Additional filtering using variants associated with the Zika related viruses and neurological disease phenotypes identified putative candidate ZIKV targets These encompass druggable proteins including adhesion molecules chemokines enzymes interleukins receptors and transporters Genes linked to Guillain Barr eacute syndrome and microcephaly was among the Zika candidate genes The protein expression of the candidate genes was detected in diverse body fluids Drug bank datamining of these candidate targets identified seventy nine FDA approved drugs of the class antineoplastics anti diabetic anti inflammatory antivirals antibiotics statins and neutraceuticals The database of genes from the study provides a framework for diagnosis and therapy of the ZVD The FDA approved list of drugs if verified may offer a repurposing use for the treatment of the ZVD" @default.
• W2464961363 created "2016-07-22" @default.
• W2464961363 creator A5000386893 @default.
• W2464961363 date "2016-03-03" @default.
• W2464961363 modified "2023-10-17" @default.
• W2464961363 title "Zika virus Therapeutics: Drug Targets and Repurposing Medicine from the Human Genome" @default.
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• W2464961363 doi "https://doi.org/10.15406/mojpb.2016.03.00084" @default.
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