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• W2465074434 abstract "Enhancers, not promoters, are the most dynamic in their DNA methylation status throughout development and differentiation. Generally speaking, enhancers that are primed to or actually drive gene expression are characterized by relatively low levels of DNA methylation (hypo-methylation), while inactive enhancers display hyper-methylation of the underlying DNA. The direct functional significance of the DNA methylation state of enhancers is, however, unclear for most loci. In contrast to conventional epigenetic interactions at enhancers, we find that DNA methylation status and enhancer activity during early zebrafish development display very unusual correlation characteristics: hypo-methylation is a unique feature of primed enhancers whereas active enhancers are generally hyper-methylated. The hypo-methylated enhancers that we identify (hypo-enhancers) are enriched close to important transcription factors that act later in development. Interestingly, hypo-enhancers are de-methylated shortly before the midblastula transition and reside in a unique epigenetic environment. Finally, we demonstrate that hypo-enhancers do become active at later developmental stages and that they are physically associated with the transcriptional start site of target genes, irrespective of target gene activity. We demonstrate that early development in zebrafish embodies a time window characterized by non-canonical DNA methylation–enhancer relationships, including global DNA hypo-methylation of inactive enhancers and DNA hyper-methylation of active enhancers." @default.
• W2465074434 created "2016-07-22" @default.
• W2465074434 creator A5004169647 @default.
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• W2465074434 date "2016-07-05" @default.
• W2465074434 modified "2023-09-24" @default.
• W2465074434 title "Enhancers reside in a unique epigenetic environment during early zebrafish development" @default.
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• W2465074434 cites W1979594866 @default.
• W2465074434 cites W1981030303 @default.
• W2465074434 cites W1981463058 @default.
• W2465074434 cites W1983347147 @default.
• W2465074434 cites W1986586739 @default.
• W2465074434 cites W1989618744 @default.
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• W2465074434 cites W1994950146 @default.
• W2465074434 cites W1998546480 @default.
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• W2465074434 cites W2008227324 @default.
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• W2465074434 doi "https://doi.org/10.1186/s13059-016-1013-1" @default.
• W2465074434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4934011" @default.
• W2465074434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27381023" @default.
• W2465074434 hasPublicationYear "2016" @default.
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