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- W2465119123 abstract "espanolEl objetivo del presente trabajo fue determinar el potencial osteogenico de la proteina morfogenetica osea (BMP) en la reparacion de grandes defectos diafisarios. Ademas, se investiga la accion coadyuvante de la fibronectina (FN). La BMP fue extraida a partir de hueso cortical bovino. Se utilizaron un total de 108 ratas Sprague Dawley. En cada animal, se reseco un segmento de diafisis femoral de 1.5 cm, siendo inmovilizado el defecto oseo con una aguja en omega. Se relleno el defecto implantando 25 mg de BMP con o sin 0.5 mg de FN en una capsula de gelatina (36 animales en ambos grupos). Los resultados se compararon con los obtenidos en otro grupo (36 animales) en el que solo se implanto FN que sirvio como grupo control. El proceso de reparacion se evaluo mediante metodos histologicos y ultraestructurales. La aparicion del fenomeno de induccion osea con reconstruccion del defecto oseo fue mayor en el grupo con implante de BMP mas FN (23 animales, 64%) que en el grupo en el que solo se implanto BMP (20 animales, 56%). Ningun animal del grupo control manifestaba signos de induccion osea. EnglishThe aim of the present work was to evaluate the osteogenic potential of Bone Morphogenetic Protein (BMP) for reparation of large segmental bone defects. In addition, the coadjuvant efect of fibronectin (FN) was investigated. BMP was partially purified from bovine cortical bone. A total of 108 Sprague Dawley rats were used in the experiment. Diaphyseal segments of the femur (1.5 cm) were removed in each animal, manteinant the bone defect with a wire. A gelatine capsula containing 25 mg of BMP without or with 0.5 mg of FN, were implanted into the bone defect (36 animal in each group). Results were compared to those obtained in a control group (36 animals) in which FN alone was implanted. The bone repair process was assessed by histologic and ultrastructural methods. Bone induction with reconstruction of the defect was found more of ten in the group with both BMP and FN implanted (23 animals, 64%) than in the group with BMP implant alone (20 animals, 56%). Animals of the control group showed no bone induction. The results suggest that BMP augments the capacity of the host bed to sucessfully regenerate large segmental bone defects. FN seens to increase bone induction. This protein migth stabilize BMP locally improving contact between BMP and the surrounding cells." @default.
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- W2465119123 date "1992-01-01" @default.
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- W2465119123 title "Aislamiento de un extracto de BMP y estudio anatomopatológico del fenómeno de inducción ósea tras su implante en defectos óseos" @default.
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