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• W2465166143 abstract "Explantate des Cerebrocortex neonataler Ratten wurden unter Zugabe von 5-Hydroxytryptamin-kreatininsulfat in einer Konzentration von 0,1 m M bis zu 15 DIV kultiviert und fluorescenzhisto-chemisch mittels der Glyoxylsäure-„heat reaction“ ( Lindvall und Björkltod 1974) untersucht. In Abhängigkeit von Kultivationsalter und/oder Pharmakoneinwirkungsdauer konnten an den unterschiedlichen Zell- und Faserelementen in den Explantaten unterschiedliche Effekte festgestellt werden. Auffällig ist eine Retardation des Wachstums. Neben gelb-grünen Fluorescenzprodukten, die als Stoffwechselmetabolite des Serotonin interpretiert werden, kommen im Explantatzentrum Zellen mit nach Glyoxylsäure-Behandlung typischer braun-gelber Fluorescenz vor. Die Ergebnisse werden im Hinblick auf die Rolle von Neurotransmittern als Modulatoren der Neurogenese in Analogie zu neuroembryologischen Ergebnissen diskutiert. Explants of the cerebrocortex of neonatal rats were cultivated up to 15 DIV in addition to 5-hydroxytryptamine creatinine sulfate at the final concentration of 0.1 m M . Fluorescence histochemical investigations were accomplished with a modified glyoxylic acid “heat reaction” according to Lindvall and Björklund (1974). Depending on the duration of the cultivation and/or influence of the 5-hydroxytryptamine creatinine sulfate in varied fiber and cell elements of the expiants varied effects were found. The retardation of the growth was striking. Yellow-greenish fluorescence is interpreted as a fluorescence of the metabolic substances of the serotonin. Cells with a brownish-yellow fluorescence typical of 5-hydroxytryptamine after treatment with glyoxylic acid in the centre of the expiants were found. Analogous to the findings of the neuroembryology in different species in situ the results were interpreted with respect to role of the neurotransmitters as modulators of the neurogenesis." @default.
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• W2465166143 title "Einfluß von 5-Hydroxytryptamin-(Serotonin-)kreatininsulfat auf die entwicklung von cerebrocortexexplantaten neonataler Ratten in vitro" @default.
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• W2465166143 doi "https://doi.org/10.1016/s0065-1281(78)80015-4" @default.
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