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- W2465184013 abstract "Cognitive deficits in type 2 diabetes mellitus (T2DM) may be partly attributable to stiffness in cerebral arteries and impaired vasodilator function, limiting the ability to increase blood flow in brain regions to meet cognitive demands. We undertook a comparison of cerebrovascular responsiveness (CVR) and cognitive performance in adults with and without T2DM. Older adults with (50) and without (Herath, Cherbuin, Eramudugolla, & Anstey, 2016) T2DM underwent transcranial Doppler ultrasound measurements of basal cerebral mean blood flow velocity (MBFV) and pulsatility index (PI), a measure of arterial stiffness, in the middle cerebral arteries (MCA). A battery of tasks assessing domains of working memory, executive function and information processing/motor speed was then administered while MBFV was recorded. CVR to cognitive tasks was calculated as a percentage increase in MBFV from the basal level. There was no difference in basal MBFV between groups. However, PI was 14% higher in the T2DM group (P < 0.05), who performed poorer across all cognitive domains assessed and displayed poorer CVR in three tasks. Cognitive performance was inversely related to the PI/MBFV ratio, an indicator of intracranial stenosis. Impaired cerebral perfusion during mental tasks is accompanied by poor cognitive performance and stiffness in the cerebral vessels." @default.
- W2465184013 created "2016-07-22" @default.
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- W2465184013 date "2017-02-01" @default.
- W2465184013 modified "2023-10-16" @default.
- W2465184013 title "Impaired cerebrovascular responsiveness and cognitive performance in adults with type 2 diabetes" @default.
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- W2465184013 doi "https://doi.org/10.1016/j.jdiacomp.2016.06.025" @default.
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