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- W2465275382 abstract "T cells play a central role in immune-homeostasis; specifically in the induction of antigen-specific adaptive immunity against pathogens and mutated self with immunological memory. The thymus is the unique organ where T cells are generated. In this review, first the complex structures and functions of various thymic microcompartments are briefly discussed to identify critical engineering targets for regeneration of thymic functions in vitro and in vivo. Then the biomimetic regenerative engineering approaches are reviewed in three categories: 1) reconstruction of 3-D thymic architecture, 2) cellular engineering, and 3) biomaterials-based artificial presentation of critical biomolecules. For each engineering approach, remaining challenges and clinical opportunities are also identified and discussed." @default.
- W2465275382 created "2016-07-22" @default.
- W2465275382 creator A5005656079 @default.
- W2465275382 creator A5054464954 @default.
- W2465275382 date "2016-06-29" @default.
- W2465275382 modified "2023-10-14" @default.
- W2465275382 title "Engineering approaches for regeneration of T lymphopoiesis" @default.
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- W2465275382 doi "https://doi.org/10.1186/s40824-016-0067-1" @default.
- W2465275382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4926289" @default.
- W2465275382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27358746" @default.
- W2465275382 hasPublicationYear "2016" @default.