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• W2465290056 abstract "Caveolae are specialized membrane domains that are critical for the correct function of endothelial cells, adipocytes and muscle cells. Caveolins and cavins are both required for caveolae formation, and assemble into a large (80S) caveolar coat complex (80S-CCC). The architecture of the 80S-CCC, however, has not been analysed. Here we study the 80S-CCC isolated from mammalian cells using negative stain EM and 3D electron cryo-tomography. We show that the 80S-CCC is a hollow sphere with a diameter of 50–80 nm, and so has the same size and shape as individual caveolar bulbs. This provides strong evidence that the distinctive membrane shape of caveolae is generated by the shape of the 80S-CCC itself. The particle appears to be made up of two layers, an inner coat composed of polygonal units of caveolins that form a polyhedral cage, and an outer filamentous coat composed of cavins. The data suggest that the peripheral cavin coat is aligned along the edges of the inner polyhedral cage, thereby providing a mechanism for the generation of a morphologically stable caveolar coat." @default.
• W2465290056 created "2016-07-22" @default.
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• W2465290056 date "2016-01-01" @default.
• W2465290056 modified "2023-10-02" @default.
• W2465290056 title "Architecture of the caveolar coat complex" @default.
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• W2465290056 doi "https://doi.org/10.1242/jcs.191262" @default.
• W2465290056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5004899" @default.
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• W2465290056 hasPublicationYear "2016" @default.
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