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• W2465306517 abstract "Backgrounds. Clinicians need guidance to address the heterogeneity of treatment responses of patients with major depressive disorder (MDD). While prediction schemes based on symptom clustering and biomarkers have so far not yielded results of sufficient strength to inform clinical decision-making, prediction schemes based on big data predictive analytic models might be more practically useful. Method. We review evidence suggesting that prediction equations based on symptoms and other easily-assessed clinical features found in previous research to predict MDD treatment outcomes might provide a foundation for developing predictive analytic clinical decision support models that could help clinicians select optimal (personalised) MDD treatments. These methods could also be useful in targeting patient subsamples for more expensive biomarker assessments. Results. Approximately two dozen baseline variables obtained from medical records or patient reports have been found repeatedly in MDD treatment trials to predict overall treatment outcomes (i.e., intervention v. control) or differential treatment outcomes (i.e., intervention A v. intervention B). Similar evidence has been found in observational studies of MDD persistence-severity. However, no treatment studies have yet attempted to develop treatment outcome equations using the full set of these predictors. Promising preliminary empirical results coupled with recent developments in statistical methodology suggest that models could be developed to provide useful clinical decision support in personalised treatment selection. These tools could also provide a strong foundation to increase statistical power in focused studies of biomarkers and MDD heterogeneity of treatment response in subsequent controlled trials. Conclusions. Coordinated efforts are needed to develop a protocol for systematically collecting information about established predictors of heterogeneity of MDD treatment response in large observational treatment studies, applying and refining these models in subsequent pragmatic trials, carrying out pooled secondary analyses to extract the maximum amount of information from these coordinated studies, and using this information to focus future discovery efforts in the segment of the patient population in which continued uncertainty about treatment response exists." @default.
• W2465306517 created "2016-07-22" @default.
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• W2465306517 date "2016-01-26" @default.
• W2465306517 modified "2023-10-05" @default.
• W2465306517 title "Using patient self-reports to study heterogeneity of treatment effects in major depressive disorder" @default.
• W2465306517 cites W105243000 @default.
• W2465306517 cites W108869947 @default.
• W2465306517 cites W1501231972 @default.
• W2465306517 cites W1516497825 @default.
• W2465306517 cites W1590736584 @default.
• W2465306517 cites W1590852549 @default.
• W2465306517 cites W1794961212 @default.
• W2465306517 cites W1912586069 @default.
• W2465306517 cites W1919766559 @default.
• W2465306517 cites W1923793693 @default.
• W2465306517 cites W1965131919 @default.
• W2465306517 cites W1966089760 @default.
• W2465306517 cites W1967079153 @default.
• W2465306517 cites W1968037426 @default.
• W2465306517 cites W1970075950 @default.
• W2465306517 cites W1972783815 @default.
• W2465306517 cites W1973902913 @default.
• W2465306517 cites W1975301241 @default.
• W2465306517 cites W1980881195 @default.
• W2465306517 cites W1984917489 @default.
• W2465306517 cites W1985330842 @default.
• W2465306517 cites W1985720480 @default.
• W2465306517 cites W1986661918 @default.
• W2465306517 cites W1987660334 @default.
• W2465306517 cites W1988465171 @default.
• W2465306517 cites W1991710403 @default.
• W2465306517 cites W1992307103 @default.
• W2465306517 cites W1992952302 @default.
• W2465306517 cites W1994256806 @default.
• W2465306517 cites W1995765208 @default.
• W2465306517 cites W1997485359 @default.
• W2465306517 cites W1998396834 @default.
• W2465306517 cites W2002262117 @default.
• W2465306517 cites W2003130956 @default.
• W2465306517 cites W2004226941 @default.
• W2465306517 cites W2004722718 @default.
• W2465306517 cites W2007217939 @default.
• W2465306517 cites W2010156137 @default.
• W2465306517 cites W2010520254 @default.
• W2465306517 cites W2015104613 @default.
• W2465306517 cites W2016180850 @default.
• W2465306517 cites W2020279836 @default.
• W2465306517 cites W2020846414 @default.
• W2465306517 cites W2022374822 @default.
• W2465306517 cites W2023036351 @default.
• W2465306517 cites W2024671640 @default.
• W2465306517 cites W2026481380 @default.
• W2465306517 cites W2032202216 @default.
• W2465306517 cites W2033377029 @default.
• W2465306517 cites W2034535453 @default.
• W2465306517 cites W2038829654 @default.
• W2465306517 cites W2042529793 @default.
• W2465306517 cites W2042944469 @default.
• W2465306517 cites W2050080989 @default.
• W2465306517 cites W2055871162 @default.
• W2465306517 cites W2056569363 @default.
• W2465306517 cites W2056841881 @default.
• W2465306517 cites W2056844009 @default.
• W2465306517 cites W2059294241 @default.
• W2465306517 cites W2059553907 @default.
• W2465306517 cites W2062423243 @default.
• W2465306517 cites W2065522386 @default.
• W2465306517 cites W2069469104 @default.
• W2465306517 cites W2070230130 @default.
• W2465306517 cites W2070428312 @default.
• W2465306517 cites W2072668343 @default.
• W2465306517 cites W2074248915 @default.
• W2465306517 cites W2075107167 @default.
• W2465306517 cites W2078018971 @default.
• W2465306517 cites W2079350349 @default.
• W2465306517 cites W2079702662 @default.
• W2465306517 cites W2085575985 @default.
• W2465306517 cites W2089781526 @default.
• W2465306517 cites W2094760216 @default.
• W2465306517 cites W2095641460 @default.
• W2465306517 cites W2097857672 @default.
• W2465306517 cites W2099703952 @default.
• W2465306517 cites W2099760358 @default.
• W2465306517 cites W2100029001 @default.
• W2465306517 cites W2100907256 @default.

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