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- W2465353437 abstract "Pulmonary hypertension is one of the major problems in the neonatal period. Free oxygen radicals play important role in the activation of pulmonary vasoconstriction. Since D-penicillamine has proved to be a strong antioxidant in newborns it was of interest to investigate the effect of the drug in the oxygen radical induced pulmonary hypertension. According to our animal experiments D-penicillamine inhibits the xanthine oxidase induced pulmonary hypertension in piglets. The same inhibitory effect was observed in the prostanoid metabolism. Could D-penicillamine be used in the treatment of pulmonary hypertension in the newborn?" @default.
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- W2465353437 date "1992-11-01" @default.
- W2465353437 modified "2023-10-14" @default.
- W2465353437 title "[D-penicillamine: old drug, new indication? D-penicillamine reduced pulmonary hypertension induced by free radicals]." @default.
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