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• W2465365838 abstract "A time economical 60 min total synthesis of (−)-oseltamivir was accomplished in a single reaction vessel over five steps. One of the key issues is reduction in the number of steps by eliminating lengthy reaction steps with substitution of a rapid epimerization step. A catalytic system consisting of three reagents, namely, diphenylprolinol silyl ether, thiourea, and acid, was developed for a rapid asymmetric Michael reaction with excellent diastereo- and enantioselectivities. All reactions were optimized in terms of not only yield and selectivity but also reaction time." @default.
• W2465365838 created "2016-07-22" @default.
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• W2465365838 date "2016-07-05" @default.
• W2465365838 modified "2023-10-18" @default.
• W2465365838 title "Time Economical Total Synthesis of (−)-Oseltamivir" @default.
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• W2465365838 doi "https://doi.org/10.1021/acs.orglett.6b01595" @default.
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