Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465382029> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2465382029 endingPage "349" @default.
- W2465382029 startingPage "343" @default.
- W2465382029 abstract "Fibroblast-like synoviocytes (FLS) express functional membranous and cytoplasmic sensors for double-stranded (ds)RNA. Notably, FLS undergo apoptosis upon transfection with the synthetic dsRNA analog poly(I:C). We here studied the mechanism of intracellular poly(I:C) recognition and subsequent cell death in FLS. FLS responded similarly to poly(I:C) or 3pRNA transfection; however, only intracellular delivery of poly(I:C) induced significant cell death, accompanied by upregulation of pro-apoptotic proteins Puma and Noxa, caspase 3 cleavage, and nuclear segregation. Knockdown of the DExD/H-box helicase MDA5 did not affect the response to intracellular poly(I:C); in contrast, knockdown of RIG-I abrogated the response to 3pRNA. Knockdown of the downstream adaptor proteins IPS, STING, and TRIF or inhibition of TBK1 did not affect the response to intracellular poly(I:C), while knockdown of IFNAR blocked intracellular poly(I:C)-mediated signaling and cell death. We conclude that a so far unknown intracellular sensor recognizes linear dsRNA and induces apoptosis in FLS." @default.
- W2465382029 created "2016-07-22" @default.
- W2465382029 creator A5012564728 @default.
- W2465382029 creator A5058085552 @default.
- W2465382029 creator A5060136306 @default.
- W2465382029 creator A5076931715 @default.
- W2465382029 creator A5086963843 @default.
- W2465382029 date "2016-08-01" @default.
- W2465382029 modified "2023-09-23" @default.
- W2465382029 title "Intracellular delivery of poly(I:C) induces apoptosis of fibroblast-like synoviocytes via an unknown dsRNA sensor" @default.
- W2465382029 cites W126111930 @default.
- W2465382029 cites W1986126905 @default.
- W2465382029 cites W2000468514 @default.
- W2465382029 cites W2006753194 @default.
- W2465382029 cites W2009531492 @default.
- W2465382029 cites W2026884464 @default.
- W2465382029 cites W2032016738 @default.
- W2465382029 cites W2036895227 @default.
- W2465382029 cites W2042173485 @default.
- W2465382029 cites W2050804496 @default.
- W2465382029 cites W2057990302 @default.
- W2465382029 cites W2063125566 @default.
- W2465382029 cites W2065577539 @default.
- W2465382029 cites W2066571367 @default.
- W2465382029 cites W2075413744 @default.
- W2465382029 cites W2076361525 @default.
- W2465382029 cites W2079045730 @default.
- W2465382029 cites W2079583991 @default.
- W2465382029 cites W2084624202 @default.
- W2465382029 cites W2088506877 @default.
- W2465382029 cites W2092728238 @default.
- W2465382029 cites W2109696635 @default.
- W2465382029 cites W2137303998 @default.
- W2465382029 cites W2137968297 @default.
- W2465382029 cites W2147814046 @default.
- W2465382029 cites W2152281757 @default.
- W2465382029 cites W2170554156 @default.
- W2465382029 cites W4248837397 @default.
- W2465382029 doi "https://doi.org/10.1016/j.bbrc.2016.06.104" @default.
- W2465382029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27343555" @default.
- W2465382029 hasPublicationYear "2016" @default.
- W2465382029 type Work @default.
- W2465382029 sameAs 2465382029 @default.
- W2465382029 citedByCount "2" @default.
- W2465382029 countsByYear W24653820292022 @default.
- W2465382029 crossrefType "journal-article" @default.
- W2465382029 hasAuthorship W2465382029A5012564728 @default.
- W2465382029 hasAuthorship W2465382029A5058085552 @default.
- W2465382029 hasAuthorship W2465382029A5060136306 @default.
- W2465382029 hasAuthorship W2465382029A5076931715 @default.
- W2465382029 hasAuthorship W2465382029A5086963843 @default.
- W2465382029 hasConcept C104317684 @default.
- W2465382029 hasConcept C127561419 @default.
- W2465382029 hasConcept C153911025 @default.
- W2465382029 hasConcept C173396325 @default.
- W2465382029 hasConcept C185592680 @default.
- W2465382029 hasConcept C190283241 @default.
- W2465382029 hasConcept C54009773 @default.
- W2465382029 hasConcept C54355233 @default.
- W2465382029 hasConcept C55493867 @default.
- W2465382029 hasConcept C79879829 @default.
- W2465382029 hasConcept C81885089 @default.
- W2465382029 hasConcept C86803240 @default.
- W2465382029 hasConcept C95444343 @default.
- W2465382029 hasConceptScore W2465382029C104317684 @default.
- W2465382029 hasConceptScore W2465382029C127561419 @default.
- W2465382029 hasConceptScore W2465382029C153911025 @default.
- W2465382029 hasConceptScore W2465382029C173396325 @default.
- W2465382029 hasConceptScore W2465382029C185592680 @default.
- W2465382029 hasConceptScore W2465382029C190283241 @default.
- W2465382029 hasConceptScore W2465382029C54009773 @default.
- W2465382029 hasConceptScore W2465382029C54355233 @default.
- W2465382029 hasConceptScore W2465382029C55493867 @default.
- W2465382029 hasConceptScore W2465382029C79879829 @default.
- W2465382029 hasConceptScore W2465382029C81885089 @default.
- W2465382029 hasConceptScore W2465382029C86803240 @default.
- W2465382029 hasConceptScore W2465382029C95444343 @default.
- W2465382029 hasIssue "3" @default.
- W2465382029 hasLocation W24653820291 @default.
- W2465382029 hasLocation W24653820292 @default.
- W2465382029 hasOpenAccess W2465382029 @default.
- W2465382029 hasPrimaryLocation W24653820291 @default.
- W2465382029 hasRelatedWork W2351114716 @default.
- W2465382029 hasRelatedWork W2355678225 @default.
- W2465382029 hasRelatedWork W2367047681 @default.
- W2465382029 hasRelatedWork W2377568735 @default.
- W2465382029 hasRelatedWork W2378483728 @default.
- W2465382029 hasRelatedWork W2379003630 @default.
- W2465382029 hasRelatedWork W2388517378 @default.
- W2465382029 hasRelatedWork W2555524919 @default.
- W2465382029 hasRelatedWork W2805656931 @default.
- W2465382029 hasRelatedWork W3127192594 @default.
- W2465382029 hasVolume "477" @default.
- W2465382029 isParatext "false" @default.
- W2465382029 isRetracted "false" @default.
- W2465382029 magId "2465382029" @default.
- W2465382029 workType "article" @default.