Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465393003> ?p ?o ?g. }
- W2465393003 endingPage "1463" @default.
- W2465393003 startingPage "1453" @default.
- W2465393003 abstract "We identified the characteristics of myeloid-derived suppressor cells (MDSCs) and investigated their mechanism of induction and their functional role in allograft rejection using a murine corneal allograft model. In mice, MDSCs coexpress CD11b and myeloid differentiation antigen Gr-1. Gr-1+CD11b+ cells infiltrated allografted corneas between 4 d and 4 wk after surgery; however, the frequencies of Gr-1+CD11b+ cells were not different between accepted and rejected allografts or in peripheral blood or BM. Of interest, Gr-1intCD11b+ cells, but not Gr-1hiCD11b+ cells, infiltrated the accepted graft early after surgery and expressed high levels of immunosuppressive cytokines, including IL-10, TGF-β, and TNF-related apoptosis-inducing ligand. This population remained until 4 wk after surgery. In vitro, only high dose (>100 ng/ml) of IFN-γ plus GM-CSF could induce immunosuppressive cytokine expression in Gr-1intCD11b+ cells. Furthermore, adoptive transfer of Gr-1intCD11b+ cells reduced T cell infiltration, which improved graft survival. In conclusion, high-dose IFN-γ in allograft areas is essential for development of Gr-1intCD11b+ MDSCs in corneal allografts, and subtle environmental changes in the early period of the allograft can result in a large difference in graft survival." @default.
- W2465393003 created "2016-07-22" @default.
- W2465393003 creator A5003683884 @default.
- W2465393003 creator A5021563195 @default.
- W2465393003 creator A5043815269 @default.
- W2465393003 creator A5049679787 @default.
- W2465393003 creator A5051121123 @default.
- W2465393003 creator A5069780944 @default.
- W2465393003 creator A5071535904 @default.
- W2465393003 creator A5072734871 @default.
- W2465393003 creator A5078201183 @default.
- W2465393003 creator A5080433925 @default.
- W2465393003 date "2016-07-01" @default.
- W2465393003 modified "2023-09-25" @default.
- W2465393003 title "Gr-1intCD11b+ myeloid-derived suppressor cells accumulate in corneal allograft and improve corneal allograft survival" @default.
- W2465393003 cites W1483867716 @default.
- W2465393003 cites W1486681462 @default.
- W2465393003 cites W1496942345 @default.
- W2465393003 cites W1525038826 @default.
- W2465393003 cites W1536028944 @default.
- W2465393003 cites W1837370850 @default.
- W2465393003 cites W1867019379 @default.
- W2465393003 cites W1917161620 @default.
- W2465393003 cites W1927103661 @default.
- W2465393003 cites W1947199545 @default.
- W2465393003 cites W1950453196 @default.
- W2465393003 cites W1982561048 @default.
- W2465393003 cites W1992702600 @default.
- W2465393003 cites W2003014847 @default.
- W2465393003 cites W2010695456 @default.
- W2465393003 cites W2011029623 @default.
- W2465393003 cites W2011473151 @default.
- W2465393003 cites W2018546690 @default.
- W2465393003 cites W2025242477 @default.
- W2465393003 cites W2032396159 @default.
- W2465393003 cites W2039358703 @default.
- W2465393003 cites W2045685765 @default.
- W2465393003 cites W2046871810 @default.
- W2465393003 cites W2056217426 @default.
- W2465393003 cites W2063917748 @default.
- W2465393003 cites W2066954245 @default.
- W2465393003 cites W2068971398 @default.
- W2465393003 cites W2070968699 @default.
- W2465393003 cites W2073826009 @default.
- W2465393003 cites W2076930318 @default.
- W2465393003 cites W2082327212 @default.
- W2465393003 cites W2088874874 @default.
- W2465393003 cites W2093011834 @default.
- W2465393003 cites W2102900782 @default.
- W2465393003 cites W2105815961 @default.
- W2465393003 cites W2122850445 @default.
- W2465393003 cites W2130988210 @default.
- W2465393003 cites W2132359386 @default.
- W2465393003 cites W2132380025 @default.
- W2465393003 cites W2132932119 @default.
- W2465393003 cites W2134421457 @default.
- W2465393003 cites W2137634455 @default.
- W2465393003 cites W2138654133 @default.
- W2465393003 cites W2139012354 @default.
- W2465393003 cites W2156013098 @default.
- W2465393003 cites W2157269800 @default.
- W2465393003 cites W2161944234 @default.
- W2465393003 cites W2163242247 @default.
- W2465393003 cites W2170697079 @default.
- W2465393003 cites W2312229537 @default.
- W2465393003 cites W2792966232 @default.
- W2465393003 cites W4236153851 @default.
- W2465393003 cites W4255053507 @default.
- W2465393003 doi "https://doi.org/10.1189/jlb.5a1115-508rr" @default.
- W2465393003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27370015" @default.
- W2465393003 hasPublicationYear "2016" @default.
- W2465393003 type Work @default.
- W2465393003 sameAs 2465393003 @default.
- W2465393003 citedByCount "8" @default.
- W2465393003 countsByYear W24653930032018 @default.
- W2465393003 countsByYear W24653930032020 @default.
- W2465393003 countsByYear W24653930032021 @default.
- W2465393003 crossrefType "journal-article" @default.
- W2465393003 hasAuthorship W2465393003A5003683884 @default.
- W2465393003 hasAuthorship W2465393003A5021563195 @default.
- W2465393003 hasAuthorship W2465393003A5043815269 @default.
- W2465393003 hasAuthorship W2465393003A5049679787 @default.
- W2465393003 hasAuthorship W2465393003A5051121123 @default.
- W2465393003 hasAuthorship W2465393003A5069780944 @default.
- W2465393003 hasAuthorship W2465393003A5071535904 @default.
- W2465393003 hasAuthorship W2465393003A5072734871 @default.
- W2465393003 hasAuthorship W2465393003A5078201183 @default.
- W2465393003 hasAuthorship W2465393003A5080433925 @default.
- W2465393003 hasConcept C121332964 @default.
- W2465393003 hasConcept C121608353 @default.
- W2465393003 hasConcept C153400128 @default.
- W2465393003 hasConcept C169760540 @default.
- W2465393003 hasConcept C171779818 @default.
- W2465393003 hasConcept C179185449 @default.
- W2465393003 hasConcept C203014093 @default.
- W2465393003 hasConcept C2776090121 @default.
- W2465393003 hasConcept C2776882836 @default.
- W2465393003 hasConcept C2779282312 @default.