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- W2465483921 abstract "Objectives: Akrinor® is a widely used drug to treat intraoperative hypotension. The drug consists of three different compounds: norepinephrine, norephedrine and theophylline. Norepinephrine and norephedrine are expected to exert sympathomimetic actions. Theophylline should inhibit PDE and therefore sensitize for cAMP-dependent positive inotropic interventions, like catecholamines. However, theophylline in Akrinor® is covalently linked to norepinephrine and norephedrine. It is not known if the potency of theophylline to inhibit PDE is preserved in such a formulation. Therefore, we have measured whether clinically used concentrations of Akrinor® inhibit PDE in human heart muscle." @default.
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- W2465483921 date "2016-01-20" @default.
- W2465483921 modified "2023-09-25" @default.
- W2465483921 title "Positive Inotropic Effects of Akrinor® in Human Atrial Tissue: Relevant PDE Inhibition at Clinically Used Concentration" @default.
- W2465483921 doi "https://doi.org/10.1055/s-0036-1571699" @default.
- W2465483921 hasPublicationYear "2016" @default.
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