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• W2465487218 startingPage "883" @default.
• W2465487218 abstract "Calcineurin is a calmodulin-stimulated phosphatase that regulates the nuclear translocation of nuclear factor of activated T cell (NFAT) c1-4 through dephosphorylation. We believe that this mechanism plays various roles in the remodeling and maintenance of Ictidomys tridecemlineatus skeletal muscle. During hibernation, bouts of torpor and arousal take place, and squirrels do not lose muscle mass despite being inactive. Protein expression of Ca2+ signaling proteins were studied using immunoblotting. A DNA-protein interaction ELISA technique was created to test the binding of NFATs in the nucleus to DNA probes containing the NFAT response element under environmental conditions reflective of those during hibernation. Calcineurin protein levels increased by 3.08-fold during torpor (compared to euthermic control), whereas calpain1 levels also rose by 3.66-fold during torpor. Calmodulin levels were elevated upon entering torpor. NFATc4 binding to DNA showed a 1.4-fold increase during torpor, and we found that this binding was further enhanced when 600 nM of Ca2+ was supplemented. We also found that decreasing the temperature of ELISAs resulted in progressive decreases in the binding of NFATs c1, c3, and c4 to DNA. In summary, calmodulin and calpain1 appear to activate calcineurin and NFATc4 during torpor. NFAT binding to target promoters is affected by intranuclear [Ca2+] and environmental temperatures. Therefore, Ca2+ signaling and temperature changes play key roles in regulation of the NFAT-calcineurin pathway in skeletal muscle of hibernating 13-lined ground squirrels over the torpor-arousal cycle, and they may contribute to the avoidance of disuse-induced muscle atrophy that occurs naturally in these animals." @default.
• W2465487218 created "2016-07-22" @default.
• W2465487218 creator A5078699661 @default.
• W2465487218 date "2016-06-25" @default.
• W2465487218 modified "2023-09-27" @default.
• W2465487218 title "Regulation of gene expression by NFAT transcription factors in hibernating ground squirrels is dependent on the cellular environment" @default.
• W2465487218 cites W1880958846 @default.
• W2465487218 cites W1969528211 @default.
• W2465487218 cites W1969900921 @default.
• W2465487218 cites W1981364887 @default.
• W2465487218 cites W1982170851 @default.
• W2465487218 cites W1992544914 @default.
• W2465487218 cites W1995563118 @default.
• W2465487218 cites W2002060477 @default.
• W2465487218 cites W2004797086 @default.
• W2465487218 cites W2005510844 @default.
• W2465487218 cites W2006459253 @default.
• W2465487218 cites W2011710975 @default.
• W2465487218 cites W2014527289 @default.
• W2465487218 cites W2014938307 @default.
• W2465487218 cites W2016668605 @default.
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• W2465487218 cites W2025217322 @default.
• W2465487218 cites W2026389064 @default.
• W2465487218 cites W2030661199 @default.
• W2465487218 cites W2031484455 @default.
• W2465487218 cites W2031612995 @default.
• W2465487218 cites W2033797333 @default.
• W2465487218 cites W2034564893 @default.
• W2465487218 cites W2036145275 @default.
• W2465487218 cites W2038005840 @default.
• W2465487218 cites W2041308924 @default.
• W2465487218 cites W2042985795 @default.
• W2465487218 cites W2047667443 @default.
• W2465487218 cites W2049625145 @default.
• W2465487218 cites W2052598888 @default.
• W2465487218 cites W2055082208 @default.
• W2465487218 cites W2070033697 @default.
• W2465487218 cites W2071617390 @default.
• W2465487218 cites W2076823362 @default.
• W2465487218 cites W2077641328 @default.
• W2465487218 cites W2078351015 @default.
• W2465487218 cites W2080345500 @default.
• W2465487218 cites W2087224286 @default.
• W2465487218 cites W2088762770 @default.
• W2465487218 cites W2089304805 @default.
• W2465487218 cites W2090278216 @default.
• W2465487218 cites W2098859322 @default.
• W2465487218 cites W2114175462 @default.
• W2465487218 cites W2114415241 @default.
• W2465487218 cites W2120840234 @default.
• W2465487218 cites W2130166595 @default.
• W2465487218 cites W2134812490 @default.
• W2465487218 cites W2135432367 @default.
• W2465487218 cites W2136563400 @default.
• W2465487218 cites W2136904722 @default.
• W2465487218 cites W2137015675 @default.
• W2465487218 cites W2137146542 @default.
• W2465487218 cites W2140707292 @default.
• W2465487218 cites W2143528835 @default.
• W2465487218 cites W2143629844 @default.
• W2465487218 cites W2146256775 @default.
• W2465487218 cites W2165113402 @default.
• W2465487218 cites W2168020094 @default.
• W2465487218 cites W2169150541 @default.
• W2465487218 cites W2172196619 @default.
• W2465487218 cites W2208224617 @default.
• W2465487218 cites W2226793285 @default.
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• W2465487218 cites W2299105000 @default.
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• W2465487218 cites W2326879084 @default.
• W2465487218 cites W2335302313 @default.
• W2465487218 cites W2407364126 @default.
• W2465487218 cites W2466672841 @default.
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• W2465487218 doi "https://doi.org/10.1007/s12192-016-0713-5" @default.
• W2465487218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5003805" @default.
• W2465487218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27344571" @default.
• W2465487218 hasPublicationYear "2016" @default.
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