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- W2465494145 abstract "Acute exercise preferentially mobilizes antigen-specific CD8+ T-cells into the bloodstream where they can be readily accessed for immunotherapeutic purposes. Although exercise is a simple and economical adjuvant to boost circulatory T-cell numbers, arduous exercise bouts might not be possible in some patient and healthy donor populations. Identifying the mechanisms underpinning the preferential redeployment of antigen-specific CD8+ T-cells with exercise might allow for the use of pharmacological interventions in lieu of exercise for ‘at risk’ patients. PURPOSE: To determine if antigen-specific CD8+ T-cells are redeployed by exercise via β2-adrenergic receptor signaling pathways independently of shear stress. METHODS: Five healthy male subjects (mean ± SD; age 32 ± 6 yrs; height 174.2 ± 3.9 cm; weight 74.4 ± 4.7 kg) underwent 30 minutes of steady state cycling exercise at +10% of blood lactate threshold cycling power under 3 different conditions separated by 7-days: (1) placebo, (2) non-preferential β1+ β2+antagonist (80 mg nadalol), and (3) β1-preferential antagonist (10 mg bisprolol) administered 3h prior to exercise in a randomized double-blind design. Blood samples were taken at baseline, at rest 3h after drug administration, immediately post-exercise, and 1 hr post-exercise. RESULTS: Compared to placebo, nadolol and bisoprolol had similar effects on lowering exercising heart rate (-24.4%) and blood pressure (-11.3%), indicating that vascular shear stress between the two drug conditions was identical. Exercise on placebo increased CD8+/CD28-/CD27- T-cell numbers 2.5-fold from baseline (mean ± std error: +183 ± 27 cells/μl). Nadalol and bisoprolol blunted 79.8% and 25.7% of this mobilization, respectively (p = 0.008). The number of antigen-specific T-cells mobilized during the bisoprolol trial was 3.7-fold greater than the nadolol trial. CONCLUSIONS: The mobilization of antigen-specific CD8+ T-cells with exercise is largely driven by β2-adrenergic receptor signaling pathways. In patients for whom exercise is not possible or desirable, clinicians may consider using preferential β2-agonists to mobilize antigen specific CD8+ T-cells from the tissues to the bloodstream where they can be easily accessed for immunotherapy." @default.
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- W2465494145 date "2016-05-01" @default.
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- W2465494145 title "Antigen-specific CD8+ T-cells Are Mobilized With Exercise Via β2-adrenergic Receptor Signaling Pathways" @default.
- W2465494145 doi "https://doi.org/10.1249/01.mss.0000487233.89112.f5" @default.
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