Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465561362> ?p ?o ?g. }
- W2465561362 endingPage "141" @default.
- W2465561362 startingPage "116" @default.
- W2465561362 abstract "Normal skeletal development requires tight coordination of transcriptional networks, signaling pathways, and biomechanical cues, and many of these pathways are dysregulated in pathological conditions affecting cartilage and bone. Recently, a significant role has been identified for long noncoding RNAs (lncRNAs) in developing and maintaining cellular phenotypes, and improvements in sequencing technologies have led to the identification of thousands of lncRNAs across diverse cell types, including the cells within cartilage and bone. It is clear that lncRNAs play critical roles in regulating gene expression. For example, they can function as epigenetic regulators in the nucleus via chromatin modulation to control gene transcription, or in the cytoplasm, where they can function as scaffolds for protein-binding partners or modulate the activity of other coding and noncoding RNAs. In this review, we discuss the growing list of lncRNAs involved in normal development and/or homeostasis of the skeletal system, the potential mechanisms by which these lncRNAs might function, and recent improvements in the methodologies available to study lncRNA functions in vitro and in vivo. Finally, we address the likely utility of lncRNAs as biomarkers and therapeutic targets for diseases of the skeletal system, including osteoarthritis, osteoporosis, and in cancers of the skeletal system." @default.
- W2465561362 created "2016-07-22" @default.
- W2465561362 creator A5029528743 @default.
- W2465561362 creator A5047330681 @default.
- W2465561362 creator A5065475049 @default.
- W2465561362 creator A5090627153 @default.
- W2465561362 date "2016-06-02" @default.
- W2465561362 modified "2023-10-12" @default.
- W2465561362 title "Emerging roles for long noncoding RNAs in skeletal biology and disease" @default.
- W2465561362 cites W14098964 @default.
- W2465561362 cites W1505917984 @default.
- W2465561362 cites W1544751778 @default.
- W2465561362 cites W1565738421 @default.
- W2465561362 cites W1565801945 @default.
- W2465561362 cites W1567262636 @default.
- W2465561362 cites W1574722884 @default.
- W2465561362 cites W1588194745 @default.
- W2465561362 cites W1599870084 @default.
- W2465561362 cites W1616327617 @default.
- W2465561362 cites W1739743960 @default.
- W2465561362 cites W1749100053 @default.
- W2465561362 cites W1764897119 @default.
- W2465561362 cites W1788197058 @default.
- W2465561362 cites W1795358129 @default.
- W2465561362 cites W1866588049 @default.
- W2465561362 cites W1867424522 @default.
- W2465561362 cites W1873856147 @default.
- W2465561362 cites W1897003648 @default.
- W2465561362 cites W1898862743 @default.
- W2465561362 cites W1916533195 @default.
- W2465561362 cites W1926959933 @default.
- W2465561362 cites W1945909693 @default.
- W2465561362 cites W1946181835 @default.
- W2465561362 cites W1956510785 @default.
- W2465561362 cites W1963807858 @default.
- W2465561362 cites W1964752771 @default.
- W2465561362 cites W1965665343 @default.
- W2465561362 cites W1965792380 @default.
- W2465561362 cites W1968116524 @default.
- W2465561362 cites W1968402436 @default.
- W2465561362 cites W1969030848 @default.
- W2465561362 cites W1969221593 @default.
- W2465561362 cites W1970742097 @default.
- W2465561362 cites W1972170164 @default.
- W2465561362 cites W1972181955 @default.
- W2465561362 cites W1973260880 @default.
- W2465561362 cites W1973445288 @default.
- W2465561362 cites W1973526125 @default.
- W2465561362 cites W1974736226 @default.
- W2465561362 cites W1975064579 @default.
- W2465561362 cites W1976727919 @default.
- W2465561362 cites W1977479530 @default.
- W2465561362 cites W1977733607 @default.
- W2465561362 cites W1977943782 @default.
- W2465561362 cites W1979768717 @default.
- W2465561362 cites W1981820702 @default.
- W2465561362 cites W1982863620 @default.
- W2465561362 cites W1985147842 @default.
- W2465561362 cites W1988963557 @default.
- W2465561362 cites W1990528489 @default.
- W2465561362 cites W1991415492 @default.
- W2465561362 cites W1992212213 @default.
- W2465561362 cites W1993846065 @default.
- W2465561362 cites W1995499476 @default.
- W2465561362 cites W1996284699 @default.
- W2465561362 cites W1997932830 @default.
- W2465561362 cites W199810177 @default.
- W2465561362 cites W1999319535 @default.
- W2465561362 cites W1999893828 @default.
- W2465561362 cites W1999914295 @default.
- W2465561362 cites W2000391476 @default.
- W2465561362 cites W2000875411 @default.
- W2465561362 cites W2002251686 @default.
- W2465561362 cites W2004914633 @default.
- W2465561362 cites W2005162347 @default.
- W2465561362 cites W2007548292 @default.
- W2465561362 cites W2009644747 @default.
- W2465561362 cites W2011566302 @default.
- W2465561362 cites W2012453729 @default.
- W2465561362 cites W2012489076 @default.
- W2465561362 cites W2012589963 @default.
- W2465561362 cites W2013575881 @default.
- W2465561362 cites W2014333311 @default.
- W2465561362 cites W2018042930 @default.
- W2465561362 cites W2018151311 @default.
- W2465561362 cites W2019744993 @default.
- W2465561362 cites W2026081091 @default.
- W2465561362 cites W2027318416 @default.
- W2465561362 cites W2027347575 @default.
- W2465561362 cites W2027736364 @default.
- W2465561362 cites W2029919331 @default.
- W2465561362 cites W2030658020 @default.
- W2465561362 cites W2031264330 @default.
- W2465561362 cites W2031539476 @default.
- W2465561362 cites W2032554521 @default.
- W2465561362 cites W2032640007 @default.
- W2465561362 cites W2034023446 @default.
- W2465561362 cites W2034355012 @default.