FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465619787> ?p ?o ?g. }

• W2465619787 endingPage "1348" @default.
• W2465619787 startingPage "1337" @default.
• W2465619787 abstract "Betulin is a pentacyclic triterpenoid isolated from the bark of yellow and white birch trees with anti-cancer and anti-malaria activities. In this study we examined the effects of betulin on atherosclerosis in apoE-/- mice and the underlying mechanisms.Murine macrophage RAW264.7 cells and human monocyte-derived THP-1 cells were tested. Foam cell formation was detected with Oil Red O staining. Cholesterol efflux was assessed using [3H]-cholesterol efflux assay. The expression of ATP-binding cassette transporter A1 and G1 (ABCA1 and ABCG1) was examined using RT-PCR and Western-blotting. The ABCA1 promoter activity was evaluated using luciferase activity assay. Male apoE-/- mice fed on a high-fat-diet (HFD), and received betulin (20 and 40 mg·kg-1·d-1, ig) for 12 weeks. The macrophage content and ABCA1 expression in the aortic sinuses were evaluated with immunofluorescence staining. The hepatic, intestinal and fecal cholesterol were also analyzed in the mice.In RAW264.7 cells, betulin (0.1-2.5 μg/mL) dose-dependently ameliorated oxLDL-induced cholesterol accumulation and enhanced cholesterol efflux. In both RAW264.7 and THP-1 cells, betulin increased the expression of ABCA1 and ABCG1 via suppressing the transcriptional repressors sterol-responsive element-binding proteins (SREBPs) that bound to E-box motifs in ABCA1 promoter, whereas E-box binding site mutation markedly attenuated betulin-induced ABCA1 promoter activity. In HFD-fed apoE-/- mice, betulin administration significantly reduced lesions in en face aortas and aortic sinuses. Furthermore, betulin administration significantly increased ABCA1 expression and suppressed macrophage positive areas in the aortic sinuses. Moreover, betulin administration improved plasma lipid profiles and enhanced fecal cholesterol excretion in the mice.Betulin attenuates atherosclerosis in apoE-/- mice by promoting cholesterol efflux in macrophages." @default.
• W2465619787 created "2016-07-22" @default.
• W2465619787 creator A5000245536 @default.
• W2465619787 creator A5008413368 @default.
• W2465619787 creator A5009985634 @default.
• W2465619787 creator A5013509330 @default.
• W2465619787 creator A5014283643 @default.
• W2465619787 creator A5022768852 @default.
• W2465619787 date "2016-07-04" @default.
• W2465619787 modified "2023-10-18" @default.
• W2465619787 title "Betulin attenuates atherosclerosis in apoE−/− mice by up-regulating ABCA1 and ABCG1" @default.
• W2465619787 cites W1570388980 @default.
• W2465619787 cites W1882790052 @default.
• W2465619787 cites W1975905715 @default.
• W2465619787 cites W1989188411 @default.
• W2465619787 cites W1990693017 @default.
• W2465619787 cites W1993306998 @default.
• W2465619787 cites W1996685034 @default.
• W2465619787 cites W2005175065 @default.
• W2465619787 cites W2015805615 @default.
• W2465619787 cites W2026587556 @default.
• W2465619787 cites W2028288720 @default.
• W2465619787 cites W2032513433 @default.
• W2465619787 cites W2033896075 @default.
• W2465619787 cites W2034911894 @default.
• W2465619787 cites W2034968148 @default.
• W2465619787 cites W2035252462 @default.
• W2465619787 cites W2038315143 @default.
• W2465619787 cites W2039999119 @default.
• W2465619787 cites W2048890665 @default.
• W2465619787 cites W2060132335 @default.
• W2465619787 cites W2063700981 @default.
• W2465619787 cites W2068080664 @default.
• W2465619787 cites W2074888173 @default.
• W2465619787 cites W2077409457 @default.
• W2465619787 cites W2082802784 @default.
• W2465619787 cites W2085017133 @default.
• W2465619787 cites W2085909854 @default.
• W2465619787 cites W2093212994 @default.
• W2465619787 cites W2093296161 @default.
• W2465619787 cites W2111482014 @default.
• W2465619787 cites W2113398622 @default.
• W2465619787 cites W2115420718 @default.
• W2465619787 cites W2119092533 @default.
• W2465619787 cites W2119188461 @default.
• W2465619787 cites W2125448572 @default.
• W2465619787 cites W2128738849 @default.
• W2465619787 cites W2128986402 @default.
• W2465619787 cites W2129745115 @default.
• W2465619787 cites W2147359941 @default.
• W2465619787 cites W2151102178 @default.
• W2465619787 cites W2159332620 @default.
• W2465619787 cites W2164799069 @default.
• W2465619787 cites W2170535838 @default.
• W2465619787 cites W36612387 @default.
• W2465619787 cites W4241771140 @default.
• W2465619787 cites W4291982393 @default.
• W2465619787 doi "https://doi.org/10.1038/aps.2016.46" @default.
• W2465619787 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5057233" @default.
• W2465619787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27374487" @default.
• W2465619787 hasPublicationYear "2016" @default.
• W2465619787 type Work @default.
• W2465619787 sameAs 2465619787 @default.
• W2465619787 citedByCount "26" @default.
• W2465619787 countsByYear W24656197872017 @default.
• W2465619787 countsByYear W24656197872018 @default.
• W2465619787 countsByYear W24656197872019 @default.
• W2465619787 countsByYear W24656197872020 @default.
• W2465619787 countsByYear W24656197872021 @default.
• W2465619787 countsByYear W24656197872022 @default.
• W2465619787 countsByYear W24656197872023 @default.
• W2465619787 crossrefType "journal-article" @default.
• W2465619787 hasAuthorship W2465619787A5000245536 @default.
• W2465619787 hasAuthorship W2465619787A5008413368 @default.
• W2465619787 hasAuthorship W2465619787A5009985634 @default.
• W2465619787 hasAuthorship W2465619787A5013509330 @default.
• W2465619787 hasAuthorship W2465619787A5014283643 @default.
• W2465619787 hasAuthorship W2465619787A5022768852 @default.
• W2465619787 hasBestOaLocation W24656197871 @default.
• W2465619787 hasConcept C104317684 @default.
• W2465619787 hasConcept C122927707 @default.
• W2465619787 hasConcept C126322002 @default.
• W2465619787 hasConcept C134018914 @default.
• W2465619787 hasConcept C149011108 @default.
• W2465619787 hasConcept C153911025 @default.
• W2465619787 hasConcept C171089720 @default.
• W2465619787 hasConcept C185592680 @default.
• W2465619787 hasConcept C200082930 @default.
• W2465619787 hasConcept C2776330080 @default.
• W2465619787 hasConcept C2777704780 @default.
• W2465619787 hasConcept C2778163477 @default.
• W2465619787 hasConcept C2778509883 @default.
• W2465619787 hasConcept C2779134260 @default.
• W2465619787 hasConcept C2780806160 @default.
• W2465619787 hasConcept C55493867 @default.
• W2465619787 hasConcept C57089818 @default.
• W2465619787 hasConcept C71924100 @default.
• W2465619787 hasConcept C86803240 @default.

• next