Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465641142> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2465641142 endingPage "52" @default.
- W2465641142 startingPage "441" @default.
- W2465641142 abstract "Thrombogenic plaques associated with acute myocardial infarction and sudden cardiac death are relatively acellular but the mechanisms responsible for cell loss are uncertain. To help elucidate this, we investigated advanced atherosclerotic lesions taken from 13 carotid arteries. The number of cells detected by the technique for identifying DNA fragmentation (occurring at apoptosis and necrosis) known as terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) technique varied in arteries from 9.6% to 40.3% and was 4 times higher in plaque (26.4 +/- 2.9%) than in the adjacent media (6.0 +/- 1.3%). The majority of TUNEL+ cells (75.5 +/- 5.6%) were smooth muscle cells (SMCs) as they also reacted with antibodies to SMC alpha-actin and myosin. TUNEL+ nuclei were found in macrophages (CD68+ cells), T-cells (CD3+ cells) and neovascular endothelial cells (von Willebrand factor: vWf+ cells) as well. From 13.0% to 34.0% (24.6 +/- 1.7%) of plaque cells stained with antibody to proliferating cell nuclear antigen (PCNA) whereas the number of PNCA+ nuclei in the adjacent media was 6 times lower (4.1 +/- 0.7%). In plaques, the number of PCNA+ cells correlated with the number of TUNEL+ cells (r = .66; p < .001) but the proportion of PCNA+ SMCs was relatively low (39.1 +/- 5.2%). Electronmicroscopic examination showed the presence of cells with condensed chromatin and convoluted cell surfaces in all arteries tested and the numbers of cells exhibiting these destructive alterations varied from 15.2% to 35.5% but no cells with typical expression of apoptotic death were detected. The results obtained indicate that all vascular cell types undergo cell death, with some prevalence in locations close to the plaque core and that intimal cells die through necrosis rather than apoptosis. We speculate that the imbalance in SMC death and proliferation may lead to acellular plaque formation." @default.
- W2465641142 created "2016-07-22" @default.
- W2465641142 creator A5023889861 @default.
- W2465641142 creator A5030280995 @default.
- W2465641142 creator A5060059885 @default.
- W2465641142 creator A5075043020 @default.
- W2465641142 date "1998-03-24" @default.
- W2465641142 modified "2023-09-23" @default.
- W2465641142 title "Cell death in atheromatous plaque of the carotid artery occurs through necrosis rather than apoptosis." @default.
- W2465641142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9509294" @default.
- W2465641142 hasPublicationYear "1998" @default.
- W2465641142 type Work @default.
- W2465641142 sameAs 2465641142 @default.
- W2465641142 citedByCount "7" @default.
- W2465641142 countsByYear W24656411422012 @default.
- W2465641142 countsByYear W24656411422014 @default.
- W2465641142 crossrefType "journal-article" @default.
- W2465641142 hasAuthorship W2465641142A5023889861 @default.
- W2465641142 hasAuthorship W2465641142A5030280995 @default.
- W2465641142 hasAuthorship W2465641142A5060059885 @default.
- W2465641142 hasAuthorship W2465641142A5075043020 @default.
- W2465641142 hasConcept C142724271 @default.
- W2465641142 hasConcept C153911025 @default.
- W2465641142 hasConcept C154113507 @default.
- W2465641142 hasConcept C185592680 @default.
- W2465641142 hasConcept C190283241 @default.
- W2465641142 hasConcept C196795494 @default.
- W2465641142 hasConcept C204232928 @default.
- W2465641142 hasConcept C31573885 @default.
- W2465641142 hasConcept C34688535 @default.
- W2465641142 hasConcept C503630168 @default.
- W2465641142 hasConcept C55493867 @default.
- W2465641142 hasConcept C71924100 @default.
- W2465641142 hasConcept C86803240 @default.
- W2465641142 hasConceptScore W2465641142C142724271 @default.
- W2465641142 hasConceptScore W2465641142C153911025 @default.
- W2465641142 hasConceptScore W2465641142C154113507 @default.
- W2465641142 hasConceptScore W2465641142C185592680 @default.
- W2465641142 hasConceptScore W2465641142C190283241 @default.
- W2465641142 hasConceptScore W2465641142C196795494 @default.
- W2465641142 hasConceptScore W2465641142C204232928 @default.
- W2465641142 hasConceptScore W2465641142C31573885 @default.
- W2465641142 hasConceptScore W2465641142C34688535 @default.
- W2465641142 hasConceptScore W2465641142C503630168 @default.
- W2465641142 hasConceptScore W2465641142C55493867 @default.
- W2465641142 hasConceptScore W2465641142C71924100 @default.
- W2465641142 hasConceptScore W2465641142C86803240 @default.
- W2465641142 hasIssue "6" @default.
- W2465641142 hasLocation W24656411421 @default.
- W2465641142 hasOpenAccess W2465641142 @default.
- W2465641142 hasPrimaryLocation W24656411421 @default.
- W2465641142 hasRelatedWork W1536213364 @default.
- W2465641142 hasRelatedWork W1968067667 @default.
- W2465641142 hasRelatedWork W1976916629 @default.
- W2465641142 hasRelatedWork W1987166209 @default.
- W2465641142 hasRelatedWork W2004864370 @default.
- W2465641142 hasRelatedWork W2006724080 @default.
- W2465641142 hasRelatedWork W2036462525 @default.
- W2465641142 hasRelatedWork W2073566054 @default.
- W2465641142 hasRelatedWork W2120599560 @default.
- W2465641142 hasRelatedWork W45127204 @default.
- W2465641142 hasVolume "11" @default.
- W2465641142 isParatext "false" @default.
- W2465641142 isRetracted "false" @default.
- W2465641142 magId "2465641142" @default.
- W2465641142 workType "article" @default.