FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465646893> ?p ?o ?g. }

• W2465646893 endingPage "145" @default.
• W2465646893 startingPage "135" @default.
• W2465646893 abstract "Heat-shock protein (HSP)-based immunotherapy is established on its adjuvant effects when applied via an extracellular approach to pulse and activate dendritic cells (DCs). Our previous studies indicate that DCs pulsed with recombinant fusion proteins of antigenic fragment and HSP70-like protein 1 (HSP70L1) are potent in stimulating antigen-specific Th1 responses. We herein evaluated the cytotoxic T cell (CTL) response by an intracellular approach of priming DCs with transfection of recombinant adenovirus-expressing the fusion gene of the 576–699 fragment of carcinoembryonic antigen (CEA) and HSP70L1. As compared with DCs pulsed with extracellular fusion protein, the DCs transfected with recombinant adenovirus expressing the fusion gene displayed equivalent mature phenotypes but less inflammatory appearance. However, the transfected DCs were superior to the pulsed DCs in inducing CEA-specific CTLs. Consistently, immunization of HLA-A2.1/H-2Kb transgene mice with the transfected DCs could induce more quantities of HLA-A2.1-restricted CEA-specific CTLs, protecting nude mice more significantly from human CEA-expressing colon tumor challenge when adoptively transferred. Mechanistic investigation indicated that intracellular expression of the fusion protein empowered the transfected DCs by activation of STAT1 possibly via inducing IFN-β and ERK pathways. Therefore, the more potent ability to induce anti-CEA CTL responses enables the DCs, which transfected with recombinant adenovirus expressing the fusion gene of antigenic CEA fragment and Th1 adjuvant, as an alternative promising approach for the immunotherapy of CEA-positive tumors." @default.
• W2465646893 created "2016-07-22" @default.
• W2465646893 creator A5009302276 @default.
• W2465646893 creator A5024554623 @default.
• W2465646893 creator A5034957547 @default.
• W2465646893 creator A5043235866 @default.
• W2465646893 creator A5060577282 @default.
• W2465646893 creator A5080125836 @default.
• W2465646893 creator A5090942414 @default.
• W2465646893 date "2016-06-27" @default.
• W2465646893 modified "2023-09-26" @default.
• W2465646893 title "HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer" @default.
• W2465646893 cites W1626393855 @default.
• W2465646893 cites W1847701810 @default.
• W2465646893 cites W1906924972 @default.
• W2465646893 cites W1922379075 @default.
• W2465646893 cites W1963749829 @default.
• W2465646893 cites W1972019822 @default.
• W2465646893 cites W1972121275 @default.
• W2465646893 cites W1992482869 @default.
• W2465646893 cites W1998871454 @default.
• W2465646893 cites W2001015172 @default.
• W2465646893 cites W2003593390 @default.
• W2465646893 cites W2008463183 @default.
• W2465646893 cites W2031568834 @default.
• W2465646893 cites W2047805090 @default.
• W2465646893 cites W2060578508 @default.
• W2465646893 cites W2065504621 @default.
• W2465646893 cites W2082066647 @default.
• W2465646893 cites W2085083869 @default.
• W2465646893 cites W2096744412 @default.
• W2465646893 cites W2097373411 @default.
• W2465646893 cites W2099161199 @default.
• W2465646893 cites W2101189282 @default.
• W2465646893 cites W2101265994 @default.
• W2465646893 cites W2102643650 @default.
• W2465646893 cites W2103144270 @default.
• W2465646893 cites W2103156663 @default.
• W2465646893 cites W2103221390 @default.
• W2465646893 cites W2106760898 @default.
• W2465646893 cites W2111014708 @default.
• W2465646893 cites W2134167421 @default.
• W2465646893 cites W2139448195 @default.
• W2465646893 cites W2140715248 @default.
• W2465646893 cites W2144546291 @default.
• W2465646893 cites W2144936254 @default.
• W2465646893 cites W2167504975 @default.
• W2465646893 cites W2171441266 @default.
• W2465646893 cites W2171654757 @default.
• W2465646893 cites W2265646490 @default.
• W2465646893 cites W2276103993 @default.
• W2465646893 cites W604954901 @default.
• W2465646893 doi "https://doi.org/10.1038/cmi.2016.33" @default.
• W2465646893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6952348" @default.
• W2465646893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31772283" @default.
• W2465646893 hasPublicationYear "2016" @default.
• W2465646893 type Work @default.
• W2465646893 sameAs 2465646893 @default.
• W2465646893 citedByCount "11" @default.
• W2465646893 countsByYear W24656468932018 @default.
• W2465646893 countsByYear W24656468932019 @default.
• W2465646893 countsByYear W24656468932021 @default.
• W2465646893 countsByYear W24656468932022 @default.
• W2465646893 crossrefType "journal-article" @default.
• W2465646893 hasAuthorship W2465646893A5009302276 @default.
• W2465646893 hasAuthorship W2465646893A5024554623 @default.
• W2465646893 hasAuthorship W2465646893A5034957547 @default.
• W2465646893 hasAuthorship W2465646893A5043235866 @default.
• W2465646893 hasAuthorship W2465646893A5060577282 @default.
• W2465646893 hasAuthorship W2465646893A5080125836 @default.
• W2465646893 hasAuthorship W2465646893A5090942414 @default.
• W2465646893 hasBestOaLocation W24656468931 @default.
• W2465646893 hasConcept C100701293 @default.
• W2465646893 hasConcept C104317684 @default.
• W2465646893 hasConcept C123894998 @default.
• W2465646893 hasConcept C147483822 @default.
• W2465646893 hasConcept C147969180 @default.
• W2465646893 hasConcept C153911025 @default.
• W2465646893 hasConcept C154317977 @default.
• W2465646893 hasConcept C167672396 @default.
• W2465646893 hasConcept C202751555 @default.
• W2465646893 hasConcept C203014093 @default.
• W2465646893 hasConcept C2776090121 @default.
• W2465646893 hasConcept C2777701055 @default.
• W2465646893 hasConcept C2778170410 @default.
• W2465646893 hasConcept C2780674031 @default.
• W2465646893 hasConcept C40767141 @default.
• W2465646893 hasConcept C502942594 @default.
• W2465646893 hasConcept C54009773 @default.
• W2465646893 hasConcept C54355233 @default.
• W2465646893 hasConcept C55493867 @default.
• W2465646893 hasConcept C59822182 @default.
• W2465646893 hasConcept C81444415 @default.
• W2465646893 hasConcept C81885089 @default.
• W2465646893 hasConcept C86803240 @default.
• W2465646893 hasConcept C8891405 @default.
• W2465646893 hasConceptScore W2465646893C100701293 @default.
• W2465646893 hasConceptScore W2465646893C104317684 @default.

• next