Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465647517> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2465647517 endingPage "455" @default.
- W2465647517 startingPage "449" @default.
- W2465647517 abstract "There has been a major improvement in our understanding in the area of the genetics of CRC in the last decade. Reason for this is partly that CRC has a strong hereditary trait and premalignant lesions are frequent and easily accessible. In the 1990-ies the mutations responsible for the adenoma-carcinoma sequence were discovered on after the other. In the second part of the review the authors discuss the genetic background of sporadic and IBD associated colorectal cancers as well as the role of genetics in the diagnosis, prognosis and prediction of therapy. Chromosomal instability (85%) and microsatellite instability with or without change in DNA methylation (15%) are the main mechanisms involved in the pathogenesis of sporadic colorectal cancers. It became evident that no ultimate mutations exist. Most of neoplasms are genetically heterogeneous, independent pathways and simultaneous tumorigenesis may exist within the same organ, also in the colon. Gene expression profile, clinical phenotype and prognosis may also vary according to the location. Similar genetic mutations may be found in IBD associated colorectal cancers, however, the typical sequence and importance of mutations is different. In future, fecal DNA testing may be an important screening tool for colorectal cancer; however, its routine use is still limited by its low sensitivity. Similarly, genetic investigation may play an increasing role in the prediction of prognosis, therapy and complication of chemotherapy. A more distant goal may be the individualization of the therapy." @default.
- W2465647517 created "2016-07-22" @default.
- W2465647517 creator A5005601386 @default.
- W2465647517 creator A5063268332 @default.
- W2465647517 date "2006-03-12" @default.
- W2465647517 modified "2023-09-23" @default.
- W2465647517 title "[Current concepts in the genetics of hereditary and sporadic colorectal cancer and the role of genetics in clinical practice: sporadic and IBD-associated colorectal tumors, significance of genetic tests in diagnosis, prognosis and assessment of chemotherapy outcome]." @default.
- W2465647517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16573174" @default.
- W2465647517 hasPublicationYear "2006" @default.
- W2465647517 type Work @default.
- W2465647517 sameAs 2465647517 @default.
- W2465647517 citedByCount "1" @default.
- W2465647517 crossrefType "journal-article" @default.
- W2465647517 hasAuthorship W2465647517A5005601386 @default.
- W2465647517 hasAuthorship W2465647517A5063268332 @default.
- W2465647517 hasConcept C104317684 @default.
- W2465647517 hasConcept C121608353 @default.
- W2465647517 hasConcept C126322002 @default.
- W2465647517 hasConcept C140752955 @default.
- W2465647517 hasConcept C143998085 @default.
- W2465647517 hasConcept C150194340 @default.
- W2465647517 hasConcept C180754005 @default.
- W2465647517 hasConcept C190727270 @default.
- W2465647517 hasConcept C204315192 @default.
- W2465647517 hasConcept C2776559941 @default.
- W2465647517 hasConcept C2779767149 @default.
- W2465647517 hasConcept C2780673598 @default.
- W2465647517 hasConcept C30481170 @default.
- W2465647517 hasConcept C501734568 @default.
- W2465647517 hasConcept C526805850 @default.
- W2465647517 hasConcept C54355233 @default.
- W2465647517 hasConcept C555283112 @default.
- W2465647517 hasConcept C60644358 @default.
- W2465647517 hasConcept C60748783 @default.
- W2465647517 hasConcept C61320498 @default.
- W2465647517 hasConcept C71924100 @default.
- W2465647517 hasConcept C86803240 @default.
- W2465647517 hasConceptScore W2465647517C104317684 @default.
- W2465647517 hasConceptScore W2465647517C121608353 @default.
- W2465647517 hasConceptScore W2465647517C126322002 @default.
- W2465647517 hasConceptScore W2465647517C140752955 @default.
- W2465647517 hasConceptScore W2465647517C143998085 @default.
- W2465647517 hasConceptScore W2465647517C150194340 @default.
- W2465647517 hasConceptScore W2465647517C180754005 @default.
- W2465647517 hasConceptScore W2465647517C190727270 @default.
- W2465647517 hasConceptScore W2465647517C204315192 @default.
- W2465647517 hasConceptScore W2465647517C2776559941 @default.
- W2465647517 hasConceptScore W2465647517C2779767149 @default.
- W2465647517 hasConceptScore W2465647517C2780673598 @default.
- W2465647517 hasConceptScore W2465647517C30481170 @default.
- W2465647517 hasConceptScore W2465647517C501734568 @default.
- W2465647517 hasConceptScore W2465647517C526805850 @default.
- W2465647517 hasConceptScore W2465647517C54355233 @default.
- W2465647517 hasConceptScore W2465647517C555283112 @default.
- W2465647517 hasConceptScore W2465647517C60644358 @default.
- W2465647517 hasConceptScore W2465647517C60748783 @default.
- W2465647517 hasConceptScore W2465647517C61320498 @default.
- W2465647517 hasConceptScore W2465647517C71924100 @default.
- W2465647517 hasConceptScore W2465647517C86803240 @default.
- W2465647517 hasIssue "10" @default.
- W2465647517 hasLocation W24656475171 @default.
- W2465647517 hasLocation W24656475172 @default.
- W2465647517 hasOpenAccess W2465647517 @default.
- W2465647517 hasPrimaryLocation W24656475171 @default.
- W2465647517 hasRelatedWork W102080932 @default.
- W2465647517 hasRelatedWork W1543803681 @default.
- W2465647517 hasRelatedWork W1761344783 @default.
- W2465647517 hasRelatedWork W2009058491 @default.
- W2465647517 hasRelatedWork W2023386324 @default.
- W2465647517 hasRelatedWork W2037336136 @default.
- W2465647517 hasRelatedWork W2038738445 @default.
- W2465647517 hasRelatedWork W2058314242 @default.
- W2465647517 hasRelatedWork W2058335285 @default.
- W2465647517 hasRelatedWork W2066292513 @default.
- W2465647517 hasRelatedWork W2132383396 @default.
- W2465647517 hasRelatedWork W2149851934 @default.
- W2465647517 hasRelatedWork W2300071990 @default.
- W2465647517 hasRelatedWork W2402965747 @default.
- W2465647517 hasRelatedWork W2419422371 @default.
- W2465647517 hasRelatedWork W2510927632 @default.
- W2465647517 hasRelatedWork W2758534612 @default.
- W2465647517 hasRelatedWork W2793887020 @default.
- W2465647517 hasRelatedWork W602626381 @default.
- W2465647517 hasRelatedWork W77401413 @default.
- W2465647517 hasVolume "147" @default.
- W2465647517 isParatext "false" @default.
- W2465647517 isRetracted "false" @default.
- W2465647517 magId "2465647517" @default.
- W2465647517 workType "article" @default.