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• W2465712076 abstract "Les contaminations respiratoires par les sets solubles de plutonium, d'americium et de curium sont envisagees soul l'angle de la solubilite du sel dans l'organisme, de sa repartition et de sa decorporation. Les phenomenes de fixation sont tres rapides: 15 min apres l'exposition, 15–45% de la quantite retenue par le poumon ont franchi l'alveole, et 10% de cette fraction sont deposes dans l'os. Apres deux mois, les seuls organes ayant une charge notable sont le poumon et le squelette. L'elimination urinaire est fonction de la solubilite dans l'organisme du sel considere. Le traitement par le DTPA est pratique soit par aerosol, soit par injection intra-muscalaire. Avec un traitement commence 24 h apres la contamination, la charge pulmonaire est reduite d'un facteur 10, la charge osseuse d'un facteur 6–10. Le DTPA diffuse plus lentement a partir du muscle et donne ainsi une charge plasmatique plus durable. Ces notions metaboliques et therapeutiques permettent de degager un schema de traitement applicable a l'homme en cas de contamination respiratoire par une solution de plutonium, d'americium ou de curium: DTPA administre sous forme d'aerosol immediatement apres la contamination, puis par voie generate. Ensuite une seance d'aerosol par semaine parait suffisante. Respiratory contamination by plutonium, americium and curium soluble salts was studied from the point of view of the salt's solubility in the body and its distribution and clearance. Uptake processes were rapid: 15 min after exposure, 15–45% of the amount retained in the lung passed through the alveoli, and 10% of this fraction was deposited in the bone. Two months later, only the lung and bone showed an appreciable burden. Urinary excretion was a function of the solubility of the salt considered. Treatment by DTPA was effected either by aerosol or intramuscular injection. When treatment was undertaken 24 hr after exposure, the lung burden was reduced by a factor of 1/10, the bone burden by a factor of 1/6–1/10. DTPA diffused more slowly from the lung than from the muscle, thus resulting in a longer lasting plasma burden. These metabolic and therapeutic data enable us to specify a treatment sequence to be applied to man in case of respiratory exposure to plutonium, americium or curium solutions: DTPA should be given as aerosol immediately after exposure, then by systemic administration. Afterwards, one aerosol administration a week should be enough." @default.
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• W2465712076 date "1971-02-01" @default.
• W2465712076 modified "2023-09-27" @default.
• W2465712076 title "Etude Metabolique Et Therapeutique Des Contaminations Respiratoires Par Certains Actinides En Solutions" @default.
• W2465712076 doi "https://doi.org/10.1097/00004032-197102000-00005" @default.
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