FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465762956> ?p ?o ?g. }

• W2465762956 endingPage "319" @default.
• W2465762956 startingPage "319" @default.
• W2465762956 abstract "Purpose: Borage oil (BO) and safflower oil (SO) are efficacious in reversing epidermal hyperproliferation, which is caused by the disruption of epidermal barrier. In this study, we compared the antiproliferative effect of dietary BO and SO. Altered metabolism of ceramide (Cer), the major lipid of epidermal barrier, was further determined by measurement of epidermal levels of individual Cer, glucosylceramide (GlcCer), and sphingomyelin (SM) species, and protein expression of Cer metabolizing enzymes. Methods: Epidermal hyperproliferation was induced in guinea pigs by a hydrogenated coconut diet (HCO) for 8 weeks. Subsequently, animals were fed diets of either BO (group HCO + BO) or SO (group HCO + SO) for 2 weeks. As controls, animals were fed BO (group BO) or HCO (group HCO) diets for 10 weeks. Results: Epidermal hyperproliferation was reversed in groups HCO + BO (67.6% of group HCO) and HCO + SO (84.5% of group HCO). Epidermal levels of Cer1/2, GlcCer-A/B, and β-glucocerebrosidase (GCase), an enzyme of GlcCer hydrolysis for Cer generation, were higher in group HCO + BO than in group HCO, and increased to levels similar to those of group BO. In addition, epidermal levels of SM1, serine palmitoyltransferase (SPT), and acidic sphingomyelinase (aSMase), enzymes of de novo Cer synthesis and SM hydrolysis for Cer generation, but not of Cer3-7, were higher in group HCO + BO than in group HCO. Despite an increase of SPT and aSMase in group HCO + SO to levels higher than in group HCO, epidermal levels of Cer1-7, GlcCer-A/B, and GCase were similar in these two groups. Notably, acidic ceramidase, an enzyme of Cer degradation, was highly expressed in group HCO + SO. Epidermal levels of GlcCer-C/D and SM-2/3 did not differ among groups. Conclusion: Dietary BO was more prominent for reversing epidermal hyperproliferation by enhancing Cer metabolism with increased levels of Cer1/2, GlcCer-A/B, and SM1 species, and of GCase proteins." @default.
• W2465762956 created "2016-07-22" @default.
• W2465762956 creator A5036038648 @default.
• W2465762956 creator A5042964985 @default.
• W2465762956 date "2015-01-01" @default.
• W2465762956 modified "2023-10-16" @default.
• W2465762956 title "Comparative effect of dietary borage oil and safflower oil on anti-proliferation and ceramide metabolism in the epidermis of essential fatty acid deficient guinea pigs" @default.
• W2465762956 cites W128536076 @default.
• W2465762956 cites W1635056602 @default.
• W2465762956 cites W1896328975 @default.
• W2465762956 cites W1969510510 @default.
• W2465762956 cites W1975986537 @default.
• W2465762956 cites W1976620131 @default.
• W2465762956 cites W1978504010 @default.
• W2465762956 cites W1987203691 @default.
• W2465762956 cites W1994348089 @default.
• W2465762956 cites W2002312006 @default.
• W2465762956 cites W2014225368 @default.
• W2465762956 cites W2026275425 @default.
• W2465762956 cites W2069813144 @default.
• W2465762956 cites W2074392865 @default.
• W2465762956 cites W2077179584 @default.
• W2465762956 cites W2085740573 @default.
• W2465762956 cites W2094406160 @default.
• W2465762956 cites W2095773864 @default.
• W2465762956 cites W2096237954 @default.
• W2465762956 cites W2099504624 @default.
• W2465762956 cites W2105361572 @default.
• W2465762956 cites W2108496496 @default.
• W2465762956 cites W2123262701 @default.
• W2465762956 cites W2136623004 @default.
• W2465762956 cites W2139002144 @default.
• W2465762956 cites W2151393258 @default.
• W2465762956 cites W2151967603 @default.
• W2465762956 cites W2303771534 @default.
• W2465762956 doi "https://doi.org/10.4163/jnh.2015.48.4.319" @default.
• W2465762956 hasPublicationYear "2015" @default.
• W2465762956 type Work @default.
• W2465762956 sameAs 2465762956 @default.
• W2465762956 citedByCount "2" @default.
• W2465762956 countsByYear W24657629562018 @default.
• W2465762956 countsByYear W24657629562020 @default.
• W2465762956 crossrefType "journal-article" @default.
• W2465762956 hasAuthorship W2465762956A5036038648 @default.
• W2465762956 hasAuthorship W2465762956A5042964985 @default.
• W2465762956 hasConcept C105702510 @default.
• W2465762956 hasConcept C185592680 @default.
• W2465762956 hasConcept C190283241 @default.
• W2465762956 hasConcept C2776458125 @default.
• W2465762956 hasConcept C2777851122 @default.
• W2465762956 hasConcept C31903555 @default.
• W2465762956 hasConcept C543025807 @default.
• W2465762956 hasConcept C55493867 @default.
• W2465762956 hasConcept C62231903 @default.
• W2465762956 hasConcept C86803240 @default.
• W2465762956 hasConceptScore W2465762956C105702510 @default.
• W2465762956 hasConceptScore W2465762956C185592680 @default.
• W2465762956 hasConceptScore W2465762956C190283241 @default.
• W2465762956 hasConceptScore W2465762956C2776458125 @default.
• W2465762956 hasConceptScore W2465762956C2777851122 @default.
• W2465762956 hasConceptScore W2465762956C31903555 @default.
• W2465762956 hasConceptScore W2465762956C543025807 @default.
• W2465762956 hasConceptScore W2465762956C55493867 @default.
• W2465762956 hasConceptScore W2465762956C62231903 @default.
• W2465762956 hasConceptScore W2465762956C86803240 @default.
• W2465762956 hasFunder F4320322034 @default.
• W2465762956 hasIssue "4" @default.
• W2465762956 hasLocation W24657629561 @default.
• W2465762956 hasOpenAccess W2465762956 @default.
• W2465762956 hasPrimaryLocation W24657629561 @default.
• W2465762956 hasRelatedWork W1996725093 @default.
• W2465762956 hasRelatedWork W1999493123 @default.
• W2465762956 hasRelatedWork W2045132615 @default.
• W2465762956 hasRelatedWork W2056800957 @default.
• W2465762956 hasRelatedWork W2065965410 @default.
• W2465762956 hasRelatedWork W2082877035 @default.
• W2465762956 hasRelatedWork W2157073142 @default.
• W2465762956 hasRelatedWork W2166513379 @default.
• W2465762956 hasRelatedWork W2926232445 @default.
• W2465762956 hasRelatedWork W2189501190 @default.
• W2465762956 hasVolume "48" @default.
• W2465762956 isParatext "false" @default.
• W2465762956 isRetracted "false" @default.
• W2465762956 magId "2465762956" @default.
• W2465762956 workType "article" @default.