Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465791071> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2465791071 endingPage "4" @default.
- W2465791071 startingPage "120" @default.
- W2465791071 abstract "The aim of this study was to evaluate if ketanserin, a selective serotoninantagonist, could improve wound healing in diabetic patients with foot ulcers and severe peripheral vascular disease. In a double blind study 40 diabetic patients with foot ulcer and a systolic toe pressure below 45 mmHg were randomly allocated to either ketanserin (20-40 mg three times a day) or placebo for a period of 3 months. The treatment was carried out on an out-patient basis by a combined medical/orthopedic foot care team at the Department of Internal Medicine, University Hospital, Lund, Sweden. Both groups were comparable regarding age, sex, duration and treatment of diabetes, cardiovascular disease and type of lesion. Wound healing (defined as intact skin for at least 3 months) or wound size reduction of 50% or more were sen in 11 out of 19 (58%) in the ketanserin group and in 7 out of 19 (37%) in the placebo group. Gangrene developed in 6 patients with placebo and 2 with ketanserin. Two patients died during the study and their ulcers were not evaluated. The systolic toe pressure was measured at admission, at end of run in, after 1 month and 3 months with strain gauge technique. Only one out of nine patients (11%) with a toe pressure below 30 mmHg in the placebo group healed or improved their ulcers compared to nine out of 16 (56%) in the ketanserin group. The healing rate in the ketanserin group was higher than expected considering the lower systolic toe pressure in this group compared to placebo at randomization (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2465791071 created "2016-07-22" @default.
- W2465791071 creator A5002667204 @default.
- W2465791071 creator A5030816476 @default.
- W2465791071 creator A5054668142 @default.
- W2465791071 creator A5084039033 @default.
- W2465791071 creator A5087691000 @default.
- W2465791071 date "1990-04-01" @default.
- W2465791071 modified "2023-09-26" @default.
- W2465791071 title "Ketanserin in the treatment of diabetic foot ulcer with severe peripheral vascular disease." @default.
- W2465791071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2254674" @default.
- W2465791071 hasPublicationYear "1990" @default.
- W2465791071 type Work @default.
- W2465791071 sameAs 2465791071 @default.
- W2465791071 citedByCount "11" @default.
- W2465791071 countsByYear W24657910712014 @default.
- W2465791071 countsByYear W24657910712016 @default.
- W2465791071 countsByYear W24657910712017 @default.
- W2465791071 countsByYear W24657910712018 @default.
- W2465791071 countsByYear W24657910712020 @default.
- W2465791071 crossrefType "journal-article" @default.
- W2465791071 hasAuthorship W2465791071A5002667204 @default.
- W2465791071 hasAuthorship W2465791071A5030816476 @default.
- W2465791071 hasAuthorship W2465791071A5054668142 @default.
- W2465791071 hasAuthorship W2465791071A5084039033 @default.
- W2465791071 hasAuthorship W2465791071A5087691000 @default.
- W2465791071 hasConcept C126322002 @default.
- W2465791071 hasConcept C134018914 @default.
- W2465791071 hasConcept C141071460 @default.
- W2465791071 hasConcept C142724271 @default.
- W2465791071 hasConcept C170493617 @default.
- W2465791071 hasConcept C204787440 @default.
- W2465791071 hasConcept C27081682 @default.
- W2465791071 hasConcept C2775864247 @default.
- W2465791071 hasConcept C2776626339 @default.
- W2465791071 hasConcept C2777466421 @default.
- W2465791071 hasConcept C2777785214 @default.
- W2465791071 hasConcept C2777858829 @default.
- W2465791071 hasConcept C42219234 @default.
- W2465791071 hasConcept C53910766 @default.
- W2465791071 hasConcept C555293320 @default.
- W2465791071 hasConcept C68312169 @default.
- W2465791071 hasConcept C71924100 @default.
- W2465791071 hasConcept C84393581 @default.
- W2465791071 hasConceptScore W2465791071C126322002 @default.
- W2465791071 hasConceptScore W2465791071C134018914 @default.
- W2465791071 hasConceptScore W2465791071C141071460 @default.
- W2465791071 hasConceptScore W2465791071C142724271 @default.
- W2465791071 hasConceptScore W2465791071C170493617 @default.
- W2465791071 hasConceptScore W2465791071C204787440 @default.
- W2465791071 hasConceptScore W2465791071C27081682 @default.
- W2465791071 hasConceptScore W2465791071C2775864247 @default.
- W2465791071 hasConceptScore W2465791071C2776626339 @default.
- W2465791071 hasConceptScore W2465791071C2777466421 @default.
- W2465791071 hasConceptScore W2465791071C2777785214 @default.
- W2465791071 hasConceptScore W2465791071C2777858829 @default.
- W2465791071 hasConceptScore W2465791071C42219234 @default.
- W2465791071 hasConceptScore W2465791071C53910766 @default.
- W2465791071 hasConceptScore W2465791071C555293320 @default.
- W2465791071 hasConceptScore W2465791071C68312169 @default.
- W2465791071 hasConceptScore W2465791071C71924100 @default.
- W2465791071 hasConceptScore W2465791071C84393581 @default.
- W2465791071 hasIssue "2" @default.
- W2465791071 hasLocation W24657910711 @default.
- W2465791071 hasOpenAccess W2465791071 @default.
- W2465791071 hasPrimaryLocation W24657910711 @default.
- W2465791071 hasRelatedWork W112005791 @default.
- W2465791071 hasRelatedWork W2013453641 @default.
- W2465791071 hasRelatedWork W2086117456 @default.
- W2465791071 hasRelatedWork W2364137865 @default.
- W2465791071 hasRelatedWork W2383725167 @default.
- W2465791071 hasRelatedWork W2407690844 @default.
- W2465791071 hasRelatedWork W2414569508 @default.
- W2465791071 hasRelatedWork W2465791071 @default.
- W2465791071 hasRelatedWork W2468943314 @default.
- W2465791071 hasRelatedWork W211357888 @default.
- W2465791071 hasVolume "9" @default.
- W2465791071 isParatext "false" @default.
- W2465791071 isRetracted "false" @default.
- W2465791071 magId "2465791071" @default.
- W2465791071 workType "article" @default.