FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465851696> ?p ?o ?g. }

• W2465851696 endingPage "e1211980" @default.
• W2465851696 startingPage "e1211980" @default.
• W2465851696 abstract "Retrotransposition of long interspersed nuclear element-1 (L1-RTP) is proposed to contribute to central nervous system (CNS) plasticity by inducing mosaicism of neuronal cells. Clinical studies have identified increased L1 copy numbers in the brains of patients with psychiatric disorders. These observations implicate that L1-RTP is important for neurogenesis and that its deregulation represents a risk factor for mental disorders. However, no supportive evidence is available for understanding the importance of L1-RTP in CNS function.To explore the physiological role of L1-RTP in CNS, we examined the L1 copy number during maturation. Interestingly, the L1 copy number increased after birth in the mouse hippocampus, but not the frontal lobe, with maximal copy numbers found in 8-week-old mice. This age-dependent L1 increase was abolished by administration of a reverse-transcriptase inhibitor, stavudine (d4T), which showed no toxic effects. Notably, the age-dependent L1 increase was attenuated by post-weaning social isolation (SI) stress, a well-known intervention for inducing psychiatric disorders in mice, or deletion of the NR2A gene that encodes a subunit of the glutamate receptor. Moreover, the negative effects of SI stress on L1-RTP were partially restored by environmental enrichment with voluntary running, but not by fluoxetine, a commonly used anti-psychiatric drug. Finally, behavioral experiments revealed that learning memory was defective in d4T-treated mice, which was similarly observed in mice raised under SI stress.We detected the modulation of L1-RTP in the hippocampus during maturation of the CNS. In a recent study, we demonstrated that stimulants such as methamphetamine and cocaine were active in the induction of L1-RTP in neuronal cells, and previous studies have shown that NR2A-deficient mice are susceptible to mental abnormality. Herein, our data support the notion that the age-dependent modulation of L1-RTP is involved in genome differentiation in the hippocampus, and that modulation defects are linked to the development of psychiatric disorders." @default.
• W2465851696 created "2016-07-22" @default.
• W2465851696 creator A5017184112 @default.
• W2465851696 creator A5048397528 @default.
• W2465851696 creator A5063973955 @default.
• W2465851696 creator A5081091607 @default.
• W2465851696 date "2016-07-03" @default.
• W2465851696 modified "2023-10-16" @default.
• W2465851696 title "Modulation of long interspersed nuclear element-1 in the mouse hippocampus during maturation" @default.
• W2465851696 cites W1789390464 @default.
• W2465851696 cites W1931569217 @default.
• W2465851696 cites W1964303494 @default.
• W2465851696 cites W1965485846 @default.
• W2465851696 cites W1969767756 @default.
• W2465851696 cites W1973860817 @default.
• W2465851696 cites W1974751543 @default.
• W2465851696 cites W1994831927 @default.
• W2465851696 cites W1995188451 @default.
• W2465851696 cites W1997078443 @default.
• W2465851696 cites W2010310827 @default.
• W2465851696 cites W2015946556 @default.
• W2465851696 cites W2019243277 @default.
• W2465851696 cites W2023979631 @default.
• W2465851696 cites W2032679533 @default.
• W2465851696 cites W2036684943 @default.
• W2465851696 cites W2036994672 @default.
• W2465851696 cites W2043614089 @default.
• W2465851696 cites W2044818530 @default.
• W2465851696 cites W2055189260 @default.
• W2465851696 cites W2063306678 @default.
• W2465851696 cites W2065919724 @default.
• W2465851696 cites W2075224242 @default.
• W2465851696 cites W2077627382 @default.
• W2465851696 cites W2082019169 @default.
• W2465851696 cites W2086289230 @default.
• W2465851696 cites W2087316628 @default.
• W2465851696 cites W2087924464 @default.
• W2465851696 cites W2097243895 @default.
• W2465851696 cites W2105946033 @default.
• W2465851696 cites W2119742125 @default.
• W2465851696 cites W2128645913 @default.
• W2465851696 cites W2141643037 @default.
• W2465851696 cites W2159202946 @default.
• W2465851696 cites W2166506784 @default.
• W2465851696 cites W2215589094 @default.
• W2465851696 cites W2253912555 @default.
• W2465851696 cites W2412836429 @default.
• W2465851696 cites W2461371855 @default.
• W2465851696 cites W2139274061 @default.
• W2465851696 doi "https://doi.org/10.1080/2159256x.2016.1211980" @default.
• W2465851696 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4993569" @default.
• W2465851696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27583186" @default.
• W2465851696 hasPublicationYear "2016" @default.
• W2465851696 type Work @default.
• W2465851696 sameAs 2465851696 @default.
• W2465851696 citedByCount "3" @default.
• W2465851696 countsByYear W24658516962020 @default.
• W2465851696 countsByYear W24658516962023 @default.
• W2465851696 crossrefType "journal-article" @default.
• W2465851696 hasAuthorship W2465851696A5017184112 @default.
• W2465851696 hasAuthorship W2465851696A5048397528 @default.
• W2465851696 hasAuthorship W2465851696A5063973955 @default.
• W2465851696 hasAuthorship W2465851696A5081091607 @default.
• W2465851696 hasBestOaLocation W24658516962 @default.
• W2465851696 hasConcept C126322002 @default.
• W2465851696 hasConcept C134018914 @default.
• W2465851696 hasConcept C148762608 @default.
• W2465851696 hasConcept C169760540 @default.
• W2465851696 hasConcept C203014093 @default.
• W2465851696 hasConcept C204232928 @default.
• W2465851696 hasConcept C2781100881 @default.
• W2465851696 hasConcept C2781161787 @default.
• W2465851696 hasConcept C4746552 @default.
• W2465851696 hasConcept C47611674 @default.
• W2465851696 hasConcept C529278444 @default.
• W2465851696 hasConcept C53927964 @default.
• W2465851696 hasConcept C71924100 @default.
• W2465851696 hasConcept C86803240 @default.
• W2465851696 hasConceptScore W2465851696C126322002 @default.
• W2465851696 hasConceptScore W2465851696C134018914 @default.
• W2465851696 hasConceptScore W2465851696C148762608 @default.
• W2465851696 hasConceptScore W2465851696C169760540 @default.
• W2465851696 hasConceptScore W2465851696C203014093 @default.
• W2465851696 hasConceptScore W2465851696C204232928 @default.
• W2465851696 hasConceptScore W2465851696C2781100881 @default.
• W2465851696 hasConceptScore W2465851696C2781161787 @default.
• W2465851696 hasConceptScore W2465851696C4746552 @default.
• W2465851696 hasConceptScore W2465851696C47611674 @default.
• W2465851696 hasConceptScore W2465851696C529278444 @default.
• W2465851696 hasConceptScore W2465851696C53927964 @default.
• W2465851696 hasConceptScore W2465851696C71924100 @default.
• W2465851696 hasConceptScore W2465851696C86803240 @default.
• W2465851696 hasIssue "4" @default.
• W2465851696 hasLocation W24658516961 @default.
• W2465851696 hasLocation W24658516962 @default.
• W2465851696 hasLocation W24658516963 @default.
• W2465851696 hasLocation W24658516964 @default.
• W2465851696 hasOpenAccess W2465851696 @default.

• next