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• W2465852457 endingPage "505" @default.
• W2465852457 startingPage "496" @default.
• W2465852457 abstract "Crohn's disease affects those individuals with polygenic risk factors. The identified risk loci indicate that the genetic architecture of Crohn's disease involves both innate and adaptive immunity and the response to the intestinal environment including the microbiome. Genetic risk alone, however, predicts only 25% of disease, indicating that other factors, including the intestinal environment, can shape the epigenome and also confer heritable risk to patients. Patients with Crohn's disease can have purely inflammatory disease, penetrating disease or fibrostenosis. Analysis of the genetic risk combined with epigenetic marks of Crohn's disease and other disease associated with organ fibrosis reveals common events are affecting the genes and pathways key to development of fibrosis. This review will focus on what is known about the mechanisms by which genetic and epigenetic risk factors determine development of fibrosis in Crohn's disease and contrast that with other fibrotic conditions." @default.
• W2465852457 created "2016-07-22" @default.
• W2465852457 creator A5003753200 @default.
• W2465852457 creator A5057652778 @default.
• W2465852457 date "2016-07-14" @default.
• W2465852457 modified "2023-10-14" @default.
• W2465852457 title "Genetic and epigenetic regulation of intestinal fibrosis" @default.
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