FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465889469> ?p ?o ?g. }

• W2465889469 endingPage "411" @default.
• W2465889469 startingPage "405" @default.
• W2465889469 abstract "Hypoxia inducible factor (HIF)-1α, a subunit of HIF transcription factor, regulates cellular response to hypoxia. In normoxic conditions, it is hydroxylated by prolyl hydroxylase (PHD)-2 and targeted for proteosomal degradation. Drugs which inhibit PHD-2 have implications in conditions arising from insufficient blood supply. β-ODAP (β-N- oxalyl-L-α, β- diaminopropionic acid), a non-protein excitatory amino acid present in Lathyrus sativus, is an α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor agonist known to activate conventional protein kinase C and stabilize HIF-1α under normoxic conditions. However, the mechanism of HIF-1α stabilization by this compound is unknown. In silico approach was used to understand the mechanism of stabilization of HIF-1α which revealed β-ODAP interacts with key amino acid residues and Fe2+ at the catalytic site of PHD-2. These results were further corroborated with luciferase HRE (hypoxia response element) reporter system in HeLa cells. Different chemical modulators of PHD-2 activity and HIF-1α levels were included in the study for comparison. Results obtained indicate that β-ODAP inhibits PHD-2 and facilitates HIF dependent HRE expression and hence, might be helpful in conditions arising from hypoxia." @default.
• W2465889469 created "2016-07-22" @default.
• W2465889469 creator A5006754497 @default.
• W2465889469 creator A5007332340 @default.
• W2465889469 creator A5021645182 @default.
• W2465889469 creator A5053483337 @default.
• W2465889469 creator A5059806113 @default.
• W2465889469 creator A5080841452 @default.
• W2465889469 creator A5089877526 @default.
• W2465889469 date "2016-11-01" @default.
• W2465889469 modified "2023-09-27" @default.
• W2465889469 title "β-N-oxalyl-L-α, β- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions" @default.
• W2465889469 cites W1503719374 @default.
• W2465889469 cites W1506297407 @default.
• W2465889469 cites W1536770091 @default.
• W2465889469 cites W1574113032 @default.
• W2465889469 cites W1675557830 @default.
• W2465889469 cites W1844723954 @default.
• W2465889469 cites W1909841186 @default.
• W2465889469 cites W1963545628 @default.
• W2465889469 cites W1975473276 @default.
• W2465889469 cites W1976603050 @default.
• W2465889469 cites W1976827638 @default.
• W2465889469 cites W1978348298 @default.
• W2465889469 cites W1978477003 @default.
• W2465889469 cites W1991201872 @default.
• W2465889469 cites W1996372375 @default.
• W2465889469 cites W1997934335 @default.
• W2465889469 cites W2003575797 @default.
• W2465889469 cites W2007522021 @default.
• W2465889469 cites W2009812264 @default.
• W2465889469 cites W2009831075 @default.
• W2465889469 cites W2013818100 @default.
• W2465889469 cites W2016160962 @default.
• W2465889469 cites W2017575850 @default.
• W2465889469 cites W2017769226 @default.
• W2465889469 cites W2021741218 @default.
• W2465889469 cites W2021983664 @default.
• W2465889469 cites W2031385405 @default.
• W2465889469 cites W2032268426 @default.
• W2465889469 cites W2033453582 @default.
• W2465889469 cites W2037299906 @default.
• W2465889469 cites W2051215275 @default.
• W2465889469 cites W2062985225 @default.
• W2465889469 cites W2064770336 @default.
• W2465889469 cites W2076838213 @default.
• W2465889469 cites W2080374319 @default.
• W2465889469 cites W2084286257 @default.
• W2465889469 cites W2086591674 @default.
• W2465889469 cites W2090200157 @default.
• W2465889469 cites W2095383320 @default.
• W2465889469 cites W2098921416 @default.
• W2465889469 cites W2100748205 @default.
• W2465889469 cites W2105236768 @default.
• W2465889469 cites W2122644092 @default.
• W2465889469 cites W2142658496 @default.
• W2465889469 cites W2144625075 @default.
• W2465889469 cites W2144670533 @default.
• W2465889469 cites W2149268957 @default.
• W2465889469 cites W2155162140 @default.
• W2465889469 cites W2155747798 @default.
• W2465889469 cites W2159745606 @default.
• W2465889469 cites W2159784040 @default.
• W2465889469 cites W2163809998 @default.
• W2465889469 cites W2169713042 @default.
• W2465889469 cites W2218975238 @default.
• W2465889469 doi "https://doi.org/10.1016/j.ejphar.2016.07.007" @default.
• W2465889469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27393459" @default.
• W2465889469 hasPublicationYear "2016" @default.
• W2465889469 type Work @default.
• W2465889469 sameAs 2465889469 @default.
• W2465889469 citedByCount "8" @default.
• W2465889469 countsByYear W24658894692018 @default.
• W2465889469 countsByYear W24658894692019 @default.
• W2465889469 countsByYear W24658894692020 @default.
• W2465889469 countsByYear W24658894692021 @default.
• W2465889469 countsByYear W24658894692023 @default.
• W2465889469 crossrefType "journal-article" @default.
• W2465889469 hasAuthorship W2465889469A5006754497 @default.
• W2465889469 hasAuthorship W2465889469A5007332340 @default.
• W2465889469 hasAuthorship W2465889469A5021645182 @default.
• W2465889469 hasAuthorship W2465889469A5053483337 @default.
• W2465889469 hasAuthorship W2465889469A5059806113 @default.
• W2465889469 hasAuthorship W2465889469A5080841452 @default.
• W2465889469 hasAuthorship W2465889469A5089877526 @default.
• W2465889469 hasConcept C104292427 @default.
• W2465889469 hasConcept C104317684 @default.
• W2465889469 hasConcept C111335760 @default.
• W2465889469 hasConcept C11960822 @default.
• W2465889469 hasConcept C160450060 @default.
• W2465889469 hasConcept C170493617 @default.
• W2465889469 hasConcept C185592680 @default.
• W2465889469 hasConcept C202751555 @default.
• W2465889469 hasConcept C2776120743 @default.
• W2465889469 hasConcept C2778938600 @default.
• W2465889469 hasConcept C515207424 @default.
• W2465889469 hasConcept C54009773 @default.
• W2465889469 hasConcept C55493867 @default.

• next