FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465919060> ?p ?o ?g. }

• W2465919060 endingPage "634" @default.
• W2465919060 startingPage "626" @default.
• W2465919060 abstract "Metabolic challenges, such as a cold environment, stimulate sympathetic neural efferent activity to white adipose tissue (WAT) to drive lipolysis, thereby increasing the availability of free fatty acids as one source of fuel for brown adipose tissue (BAT) thermogenesis. WAT is also innervated by sensory nerve fibers that network to metabolic brain areas; moreover, activation of these afferents is reported to increase sympathetic nervous system outflow. However, the endogenous stimuli sufficient to drive WAT afferents during metabolic challenges as well as their functional relation to BAT thermogenesis remain unknown. We tested if local WAT lipolysis directly activates WAT afferent nerves, and then assessed whether this WAT sensory signal affected BAT thermogenesis in Siberian hamsters (Phodopus sungorus). 2-deoxyglucose, a sympathetic nervous system stimulant, caused β-adrenergic receptor dependent increases in inguinal WAT (IWAT) afferent neurophysiological activity. In addition, direct IWAT injections of the β3-AR agonist CL316,243 dose-dependently increased: 1) phosphorylation of IWAT hormone sensitive lipase, an indicator of SNS-stimulated lipolysis, 2) expression of the neuronal activation marker c-Fos in dorsal root ganglion neurons receiving sensory input from IWAT, and 3) IWAT afferent neurophysiological activity, an increase blocked by antilipolytic agent 3,5-dimethylpyrazole. Finally, we demonstrated that IWAT afferent activation by lipolysis triggers interscapular BAT thermogenesis through a neural link between these two tissues. These data suggest IWAT lipolysis activates local IWAT afferents triggering a neural circuit from WAT to BAT that acutely induces BAT thermogenesis." @default.
• W2465919060 created "2016-07-22" @default.
• W2465919060 creator A5011731801 @default.
• W2465919060 creator A5013369091 @default.
• W2465919060 creator A5017567018 @default.
• W2465919060 creator A5022208279 @default.
• W2465919060 creator A5063521272 @default.
• W2465919060 creator A5090570583 @default.
• W2465919060 date "2016-08-01" @default.
• W2465919060 modified "2023-10-15" @default.
• W2465919060 title "Lipolysis sensation by white fat afferent nerves triggers brown fat thermogenesis" @default.
• W2465919060 cites W164799835 @default.
• W2465919060 cites W184177557 @default.
• W2465919060 cites W1871035437 @default.
• W2465919060 cites W1897474138 @default.
• W2465919060 cites W1904953473 @default.
• W2465919060 cites W1964904380 @default.
• W2465919060 cites W1968396104 @default.
• W2465919060 cites W1974432261 @default.
• W2465919060 cites W1995902345 @default.
• W2465919060 cites W2001868230 @default.
• W2465919060 cites W2009442511 @default.
• W2465919060 cites W2013063092 @default.
• W2465919060 cites W2020447893 @default.
• W2465919060 cites W2028152208 @default.
• W2465919060 cites W2031263935 @default.
• W2465919060 cites W2032406386 @default.
• W2465919060 cites W2039586183 @default.
• W2465919060 cites W2054113726 @default.
• W2465919060 cites W2060313221 @default.
• W2465919060 cites W2065987916 @default.
• W2465919060 cites W2070843243 @default.
• W2465919060 cites W2077864709 @default.
• W2465919060 cites W2078145569 @default.
• W2465919060 cites W2079649022 @default.
• W2465919060 cites W2080145415 @default.
• W2465919060 cites W2085810766 @default.
• W2465919060 cites W2101271809 @default.
• W2465919060 cites W2104210002 @default.
• W2465919060 cites W2109660552 @default.
• W2465919060 cites W2113663557 @default.
• W2465919060 cites W2129744834 @default.
• W2465919060 cites W2131254253 @default.
• W2465919060 cites W2131256997 @default.
• W2465919060 cites W2133807445 @default.
• W2465919060 cites W2139041067 @default.
• W2465919060 cites W2154293323 @default.
• W2465919060 cites W2158874060 @default.
• W2465919060 cites W2160099505 @default.
• W2465919060 cites W2162977729 @default.
• W2465919060 cites W2165084989 @default.
• W2465919060 cites W2197183435 @default.
• W2465919060 cites W2199807322 @default.
• W2465919060 cites W2290905631 @default.
• W2465919060 cites W2306402044 @default.
• W2465919060 cites W2317440431 @default.
• W2465919060 cites W2336462396 @default.
• W2465919060 doi "https://doi.org/10.1016/j.molmet.2016.06.013" @default.
• W2465919060 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5021673" @default.
• W2465919060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27656400" @default.
• W2465919060 hasPublicationYear "2016" @default.
• W2465919060 type Work @default.
• W2465919060 sameAs 2465919060 @default.
• W2465919060 citedByCount "59" @default.
• W2465919060 countsByYear W24659190602017 @default.
• W2465919060 countsByYear W24659190602018 @default.
• W2465919060 countsByYear W24659190602019 @default.
• W2465919060 countsByYear W24659190602020 @default.
• W2465919060 countsByYear W24659190602021 @default.
• W2465919060 countsByYear W24659190602022 @default.
• W2465919060 countsByYear W24659190602023 @default.
• W2465919060 crossrefType "journal-article" @default.
• W2465919060 hasAuthorship W2465919060A5011731801 @default.
• W2465919060 hasAuthorship W2465919060A5013369091 @default.
• W2465919060 hasAuthorship W2465919060A5017567018 @default.
• W2465919060 hasAuthorship W2465919060A5022208279 @default.
• W2465919060 hasAuthorship W2465919060A5063521272 @default.
• W2465919060 hasAuthorship W2465919060A5090570583 @default.
• W2465919060 hasBestOaLocation W24659190601 @default.
• W2465919060 hasConcept C126322002 @default.
• W2465919060 hasConcept C134018914 @default.
• W2465919060 hasConcept C140985366 @default.
• W2465919060 hasConcept C151279926 @default.
• W2465919060 hasConcept C151955695 @default.
• W2465919060 hasConcept C169760540 @default.
• W2465919060 hasConcept C171089720 @default.
• W2465919060 hasConcept C185592680 @default.
• W2465919060 hasConcept C2776533406 @default.
• W2465919060 hasConcept C2780642333 @default.
• W2465919060 hasConcept C71924100 @default.
• W2465919060 hasConcept C84393581 @default.
• W2465919060 hasConcept C86803240 @default.
• W2465919060 hasConceptScore W2465919060C126322002 @default.
• W2465919060 hasConceptScore W2465919060C134018914 @default.
• W2465919060 hasConceptScore W2465919060C140985366 @default.
• W2465919060 hasConceptScore W2465919060C151279926 @default.
• W2465919060 hasConceptScore W2465919060C151955695 @default.
• W2465919060 hasConceptScore W2465919060C169760540 @default.

• next