FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2465965522> ?p ?o ?g. }

• W2465965522 endingPage "189" @default.
• W2465965522 startingPage "189" @default.
• W2465965522 abstract "AbstrakKanker payudara stadium lanjut pada usia muda dikaitkan dengan gambaran klinis, patologis dan prognosis yang lebih buruk dibanding usia tua. Ovariektomi merupakan terapi paliatif yang efektif pada pasien ini, dengan menurunkan kadar estradiol yang akan mempengaruhi gen yang terlibat dalam proses proliferasi, diferensiasi, metastasis, angiogenesis, invasi, dan apoptosis. Penelitian ini bertujuan untuk mengetahui pengaruh ovariektomi terhadap kadar VEGF, TGF β, IGF dan CA15-3 pada pasien kanker payudara stadium lanjut usia muda. Penelitian ini menggunakan desain pre dan post test pada 12 pasien kanker payudara stadium lanjut usia muda sebagai subyek penelitian. Pemeriksaan kadar VEGF, TGF β, IGF dan CA 15-3 dilakukan sebelum dan tiga bulan sesudah pasien dilakukan tindakan ovariektomi dengan menggunakan teknik ELISA, kemudian dilakukan analisis statistik dengan uji non parametrik. Penelitian menemukan peningkatan kadar VEGF, TGF β, IGF dan CA 15-3 dan menurun sesudah dilakukan ovariektomi. Analisis statistik menunjukkan pengaruh ovariektomi yang bermakna terhadap penurunan kadar VEGF (p=0,023), TGF β (p=0,02), dan CA 15-3 (p=0,002), tetapi tidak berpengaruh terhadap kadar IGF(p=875). Ovariektomi dapat menurunkan kadar VEGF, TGF β dan CA 15-3 serum, sehingga dapat dipertimbangkan sebagai terapi pilihan pada kanker payudara stadium lanjut usia muda.AbstractAdvanced breast cancer in young age is associated with worse clinical features, pathology and prognosis than old age. Oophorectomy may be an effective palliative therapy in these patients, by decreasing estradiol concentration which will affect genes involved in proliferation, differentiation, metastasis, angiogenesis, invasion, and apoptosis. This research aimed at examining the effect of oophorectomy on the levels of VEGF, TGF-β, IGF and CA15-3 in patients with advanced breast cancer in young age. This study used a pre and post test design in twelve patients with advanced breast cancer in young age. The level of VEGF, TGF-β, IGF and CA 15-3 was measured before and three months after oophorectomy using the ELISA technique. Data was analyzed with non-parametric test. Of the twelve patients studied, there were increased levels of VEGF, TGF-β, IGF, and CA 15-3 before oophorectomy and there was a decrease after oophorectomy performed. Statistical analysis showed that oophorectomy significantly decreased levels of VEGF (p = 0,023), TGF-β (p = 0,02), and CA 15-3 (p = 0,002), but no significant effect on the decrease in IGF levels (p = 0,875 ). Oophorectomy reduces levels of VEGF, TGF β and CA 15-3 serum significantly in the first three months of observation. Thus, it could be considered for the management of advanced breast cancer in young age." @default.
• W2465965522 created "2016-07-22" @default.
• W2465965522 creator A5015224806 @default.
• W2465965522 creator A5030438612 @default.
• W2465965522 creator A5030518366 @default.
• W2465965522 creator A5084468995 @default.
• W2465965522 date "2015-04-04" @default.
• W2465965522 modified "2023-10-14" @default.
• W2465965522 title "PENGARUH OVARIEKTOMI TERHADAP KADAR VEGF,TGF-β, IGF, DAN CA15-3 PADA PASIEN KANKER PAYUDARA STADIUM LANJUT USIA MUDA" @default.
• W2465965522 doi "https://doi.org/10.22338/mka.v38.i3.p189-200.2015" @default.
• W2465965522 hasPublicationYear "2015" @default.
• W2465965522 type Work @default.
• W2465965522 sameAs 2465965522 @default.
• W2465965522 citedByCount "0" @default.
• W2465965522 crossrefType "journal-article" @default.
• W2465965522 hasAuthorship W2465965522A5015224806 @default.
• W2465965522 hasAuthorship W2465965522A5030438612 @default.
• W2465965522 hasAuthorship W2465965522A5030518366 @default.
• W2465965522 hasAuthorship W2465965522A5084468995 @default.
• W2465965522 hasBestOaLocation W24659655221 @default.
• W2465965522 hasConcept C118131993 @default.
• W2465965522 hasConcept C126322002 @default.
• W2465965522 hasConcept C143998085 @default.
• W2465965522 hasConcept C167734588 @default.
• W2465965522 hasConcept C2780394083 @default.
• W2465965522 hasConcept C29456083 @default.
• W2465965522 hasConcept C71924100 @default.
• W2465965522 hasConceptScore W2465965522C118131993 @default.
• W2465965522 hasConceptScore W2465965522C126322002 @default.
• W2465965522 hasConceptScore W2465965522C143998085 @default.
• W2465965522 hasConceptScore W2465965522C167734588 @default.
• W2465965522 hasConceptScore W2465965522C2780394083 @default.
• W2465965522 hasConceptScore W2465965522C29456083 @default.
• W2465965522 hasConceptScore W2465965522C71924100 @default.
• W2465965522 hasIssue "3" @default.
• W2465965522 hasLocation W24659655221 @default.
• W2465965522 hasOpenAccess W2465965522 @default.
• W2465965522 hasPrimaryLocation W24659655221 @default.
• W2465965522 hasRelatedWork W1035133186 @default.
• W2465965522 hasRelatedWork W1550975546 @default.
• W2465965522 hasRelatedWork W2049659078 @default.
• W2465965522 hasRelatedWork W2121476609 @default.
• W2465965522 hasRelatedWork W2356322604 @default.
• W2465965522 hasRelatedWork W2359042838 @default.
• W2465965522 hasRelatedWork W2789448498 @default.
• W2465965522 hasRelatedWork W2897496508 @default.
• W2465965522 hasRelatedWork W3151919937 @default.
• W2465965522 hasRelatedWork W4232025600 @default.
• W2465965522 hasVolume "38" @default.
• W2465965522 isParatext "false" @default.
• W2465965522 isRetracted "false" @default.
• W2465965522 magId "2465965522" @default.
• W2465965522 workType "article" @default.