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- W2465977237 abstract "1 Dendritic cells (DCs) are critical antigen presenting cells that link the innate and 2 adaptive immune systems. DCs are activated through a variety of receptors and respond 3 with a diverse array of metabolic changes that are not yet well understood. IL-1β is a key 4 inflammatory cytokine produced by DCs when they are activated through both toll-like 5 receptors and C-type lectin receptors. IL-1β is activated by the inflammasome signaling 6 complex but how the inflammasome is controlled by glycolysis is not yet well understood. 7 We demonstrate that DC activation through TLR or C-type lectin receptors induces a shift 8 to aerobic glycolytic metabolism. We show that while the transcription of IL-1β in DCs 9 activated through both these receptors is not under glycolytic control, whether or not 10 translation of IL-1β is under glycolytic control remains unclear. These findings provide new 11 information on Dectin-1 mediated metabolic reprogramming in DCs. Understanding the 12 link between metabolic changes and Dectin-1-mediated DC activation has broad 13 implications for improved vaccine design and clinical intervention to fungal infection. 14 15 Introduction 16 Overview of Dendritic Cells 17 Dendritic cells (DCs), a type of innate immune cell, are specialized for patrolling 18 tissue for pathogens and presenting peptides from these pathogens to other immune cells 19 in order to activate inflammatory responses. Functionally, DCs are the link between the 20 innate and adaptive immune systems (Hoebe, Janssen, & Beutler, 2004). Innate immunity 21 refers to the cells including DCs, macrophages, and neutrophils that can recognize 22" @default.
- W2465977237 created "2016-07-22" @default.
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- W2465977237 date "2016-01-01" @default.
- W2465977237 modified "2023-09-27" @default.
- W2465977237 title "Dectin-1 Mediated Regulation of Dendritic Cell Metabolism" @default.
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- W2465977237 hasPublicationYear "2016" @default.
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