Matches in SemOpenAlex for { <https://semopenalex.org/work/W2466094870> ?p ?o ?g. }
- W2466094870 endingPage "30" @default.
- W2466094870 startingPage "23" @default.
- W2466094870 abstract "The conversion of proteins into amyloid fibrils and other amyloid-like aggregates is closely connected to the onset of a series of age-related pathologies. Upon changes in environmental conditions, amyloid-like aggregates may also undergo disassembly into oligomeric aggregates, the latter being recognized as key effectors in toxicity. This indicates new possible routes for in vivo accumulation of toxic species. In the light of the recognized implication of α-Synuclein (αSN) in Parkinson's disease, we present an experimental study on supramolecular assembly of αSN with a focus on stability and disassembly paths of such supramolecular aggregate species. Using spectroscopic techniques, two-photon microscopy, small-angle X-ray scattering and atomic force microscopy, we report evidences on how the stability of αSN amyloid-like aggregates can be altered by changing solution conditions. We show that amyloid-like aggregate formation can be induced at high temperature in the presence of trifluoroethanol (TFE). Moreover, sudden disassembly or further structural reorganisation toward higher hierarchical species can be induced by varying TFE concentration. Our results may contribute in deciphering fundamental mechanisms and interactions underlying supramolecular clustering/dissolution of αSN oligomers in cells." @default.
- W2466094870 created "2016-07-22" @default.
- W2466094870 creator A5024210312 @default.
- W2466094870 creator A5031110003 @default.
- W2466094870 creator A5040804836 @default.
- W2466094870 creator A5053725102 @default.
- W2466094870 creator A5070518688 @default.
- W2466094870 creator A5089720811 @default.
- W2466094870 date "2016-09-01" @default.
- W2466094870 modified "2023-09-30" @default.
- W2466094870 title "Trifluoroethanol modulates α-synuclein amyloid-like aggregate formation, stability and dissolution" @default.
- W2466094870 cites W1500540324 @default.
- W2466094870 cites W1588296570 @default.
- W2466094870 cites W1966692893 @default.
- W2466094870 cites W1969130034 @default.
- W2466094870 cites W1975315404 @default.
- W2466094870 cites W1977682751 @default.
- W2466094870 cites W1978874279 @default.
- W2466094870 cites W1980825524 @default.
- W2466094870 cites W1986469135 @default.
- W2466094870 cites W1987079564 @default.
- W2466094870 cites W1989386714 @default.
- W2466094870 cites W1991347541 @default.
- W2466094870 cites W1997449658 @default.
- W2466094870 cites W1997498532 @default.
- W2466094870 cites W2000276790 @default.
- W2466094870 cites W2002506451 @default.
- W2466094870 cites W2009284411 @default.
- W2466094870 cites W2015426525 @default.
- W2466094870 cites W2030187848 @default.
- W2466094870 cites W2035232504 @default.
- W2466094870 cites W2044849008 @default.
- W2466094870 cites W2050375429 @default.
- W2466094870 cites W2050786534 @default.
- W2466094870 cites W2051828749 @default.
- W2466094870 cites W2056410814 @default.
- W2466094870 cites W2062919641 @default.
- W2466094870 cites W2063583344 @default.
- W2466094870 cites W2063827082 @default.
- W2466094870 cites W2068848980 @default.
- W2466094870 cites W2075515531 @default.
- W2466094870 cites W2080462298 @default.
- W2466094870 cites W2080751623 @default.
- W2466094870 cites W2088395760 @default.
- W2466094870 cites W2089522371 @default.
- W2466094870 cites W2093201611 @default.
- W2466094870 cites W2093713022 @default.
- W2466094870 cites W2101137168 @default.
- W2466094870 cites W2109727228 @default.
- W2466094870 cites W2111215816 @default.
- W2466094870 cites W2115713105 @default.
- W2466094870 cites W2118676940 @default.
- W2466094870 cites W2121753059 @default.
- W2466094870 cites W2121937669 @default.
- W2466094870 cites W2122960770 @default.
- W2466094870 cites W2123606696 @default.
- W2466094870 cites W2127415878 @default.
- W2466094870 cites W2132154794 @default.
- W2466094870 cites W2133272695 @default.
- W2466094870 cites W2134661315 @default.
- W2466094870 cites W2136950697 @default.
- W2466094870 cites W2138698547 @default.
- W2466094870 cites W2149081087 @default.
- W2466094870 cites W2154721456 @default.
- W2466094870 cites W2160171025 @default.
- W2466094870 cites W2164627569 @default.
- W2466094870 cites W2165186407 @default.
- W2466094870 cites W2222900719 @default.
- W2466094870 cites W2314605806 @default.
- W2466094870 cites W2321181342 @default.
- W2466094870 cites W2322553001 @default.
- W2466094870 cites W2949899388 @default.
- W2466094870 doi "https://doi.org/10.1016/j.bpc.2016.06.003" @default.
- W2466094870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27372900" @default.
- W2466094870 hasPublicationYear "2016" @default.
- W2466094870 type Work @default.
- W2466094870 sameAs 2466094870 @default.
- W2466094870 citedByCount "9" @default.
- W2466094870 countsByYear W24660948702016 @default.
- W2466094870 countsByYear W24660948702017 @default.
- W2466094870 countsByYear W24660948702020 @default.
- W2466094870 countsByYear W24660948702022 @default.
- W2466094870 countsByYear W24660948702023 @default.
- W2466094870 crossrefType "journal-article" @default.
- W2466094870 hasAuthorship W2466094870A5024210312 @default.
- W2466094870 hasAuthorship W2466094870A5031110003 @default.
- W2466094870 hasAuthorship W2466094870A5040804836 @default.
- W2466094870 hasAuthorship W2466094870A5053725102 @default.
- W2466094870 hasAuthorship W2466094870A5070518688 @default.
- W2466094870 hasAuthorship W2466094870A5089720811 @default.
- W2466094870 hasConcept C115624301 @default.
- W2466094870 hasConcept C120665830 @default.
- W2466094870 hasConcept C121332964 @default.
- W2466094870 hasConcept C12554922 @default.
- W2466094870 hasConcept C131888329 @default.
- W2466094870 hasConcept C136238340 @default.
- W2466094870 hasConcept C14631669 @default.
- W2466094870 hasConcept C155672457 @default.