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- W2466136959 abstract "Background: This study investigated the effect of lithium monotherapy on peripheral lymphocyte gene expression in bipolar disorder (BD). Method: Twenty-two medication-free bipolar subjects (11 hypomanic, 11 depressed) were started on lithium monotherapy. Closely matched healthy subjects (n = 15) were included as controls but did not receive treatment. Blood RNA samples were collected at baseline and after 2 and 8 weeks of treatment. RNA expression was measured using the Affymetrix GeneChip® Human Gene 1.0 ST Array followed by Ingenuity pathways analysis. The results for the contrast of weeks 2 and 8 were not significantly different and were combined. Results: In BD subjects, 56 genes showed significant (false discovery rate Conclusion: Peripheral gene expression may serve as a biomarker of lithium effect." @default.
- W2466136959 created "2016-07-22" @default.
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- W2466136959 date "2016-06-28" @default.
- W2466136959 modified "2023-09-23" @default.
- W2466136959 title "Supplementary Material for: Effects of Lithium Monotherapy for Bipolar Disorder on Gene Expression in Peripheral Lymphocytes" @default.
- W2466136959 doi "https://doi.org/10.6084/m9.figshare.3465356.v1" @default.
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