FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2466312702> ?p ?o ?g. }

• W2466312702 abstract "Early life neuronal exposure to environmental toxicants has been suggested to be an important etiology of neurodegenerative disease development. Perfluorohexanesulfonate (PFHxS), one of the major perfluoroalkyl compounds, is widely distributed environmental contaminants. We have reported that PFHxS induces neuronal apoptosis via ERK-mediated pathway. Imperatorin is a furanocoumarin found in various edible plants and has a wide range of pharmacological effects including neuroprotection. In this study, the effects of imperatorin on PFHxS-induced neuronal apoptosis and the underlying mechanisms are examined using cerebellar granule cells (CGC). CGC were isolated from seven-day old rats and were grown in culture for seven days. Caspase-3 activity and TUNEL staining were used to determine neuronal apoptosis. PFHxS-induced apoptosis of CGC was significantly reduced by imperatorin and PD98059, an ERK pathway inhibitor. PFHxS induced a persistent increase in intracellular calcium, which was significantly blocked by imperatorin, NMDA receptor antagonist, MK801 and the L-type voltage-dependent calcium channel blockers, diltiazem and nifedipine. The activation of caspase-3 by PFHxS was also inhibited by MK801, diltiazem and nifedipine. PFHxS-increased ERK activation was inhibited by imperatorin, MK801, diltiazem and nifedipine. Taken together, imperatorin protects CGC against PFHxS-induced apoptosis via inhibition of NMDA receptor/intracellular calcium-mediated ERK pathway." @default.
• W2466312702 created "2016-07-22" @default.
• W2466312702 creator A5004999881 @default.
• W2466312702 creator A5012424400 @default.
• W2466312702 creator A5056306660 @default.
• W2466312702 creator A5091189457 @default.
• W2466312702 date "2016-01-01" @default.
• W2466312702 modified "2023-09-26" @default.
• W2466312702 title "Preventive effects of imperatorin on perfluorohexanesulfonate-induced neuronal apoptosis via inhibition of intracellular calcium-mediated ERK pathway" @default.
• W2466312702 cites W1007495478 @default.
• W2466312702 cites W1079868914 @default.
• W2466312702 cites W133907179 @default.
• W2466312702 cites W1864763562 @default.
• W2466312702 cites W1877986816 @default.
• W2466312702 cites W1963529089 @default.
• W2466312702 cites W1966209976 @default.
• W2466312702 cites W1967117930 @default.
• W2466312702 cites W1972262457 @default.
• W2466312702 cites W1973555325 @default.
• W2466312702 cites W1975793344 @default.
• W2466312702 cites W1980197057 @default.
• W2466312702 cites W1982368211 @default.
• W2466312702 cites W1983667216 @default.
• W2466312702 cites W1984971294 @default.
• W2466312702 cites W1993245057 @default.
• W2466312702 cites W1993904537 @default.
• W2466312702 cites W1998624159 @default.
• W2466312702 cites W2004585737 @default.
• W2466312702 cites W2007925359 @default.
• W2466312702 cites W2020898456 @default.
• W2466312702 cites W2031215528 @default.
• W2466312702 cites W2032786136 @default.
• W2466312702 cites W2033122881 @default.
• W2466312702 cites W2052712042 @default.
• W2466312702 cites W2053171398 @default.
• W2466312702 cites W2054857631 @default.
• W2466312702 cites W2058384275 @default.
• W2466312702 cites W2059707255 @default.
• W2466312702 cites W2061630916 @default.
• W2466312702 cites W2065790423 @default.
• W2466312702 cites W2074807178 @default.
• W2466312702 cites W2075101825 @default.
• W2466312702 cites W2079437966 @default.
• W2466312702 cites W2083115396 @default.
• W2466312702 cites W2083139279 @default.
• W2466312702 cites W2084624454 @default.
• W2466312702 cites W2088545066 @default.
• W2466312702 cites W2090455088 @default.
• W2466312702 cites W2090938600 @default.
• W2466312702 cites W2091027628 @default.
• W2466312702 cites W2101298801 @default.
• W2466312702 cites W2112558380 @default.
• W2466312702 cites W2126888533 @default.
• W2466312702 cites W2142998289 @default.
• W2466312702 cites W2145385610 @default.
• W2466312702 cites W2148450715 @default.
• W2466312702 cites W2150571811 @default.
• W2466312702 cites W2200083851 @default.
• W2466312702 cites W4230704132 @default.
• W2466312702 cites W616948281 @default.
• W2466312702 doi "https://doi.org/10.4196/kjpp.2016.20.4.399" @default.
• W2466312702 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4930908" @default.
• W2466312702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27382356" @default.
• W2466312702 hasPublicationYear "2016" @default.
• W2466312702 type Work @default.
• W2466312702 sameAs 2466312702 @default.
• W2466312702 citedByCount "11" @default.
• W2466312702 countsByYear W24663127022017 @default.
• W2466312702 countsByYear W24663127022018 @default.
• W2466312702 countsByYear W24663127022019 @default.
• W2466312702 countsByYear W24663127022020 @default.
• W2466312702 countsByYear W24663127022021 @default.
• W2466312702 countsByYear W24663127022022 @default.
• W2466312702 crossrefType "journal-article" @default.
• W2466312702 hasAuthorship W2466312702A5004999881 @default.
• W2466312702 hasAuthorship W2466312702A5012424400 @default.
• W2466312702 hasAuthorship W2466312702A5056306660 @default.
• W2466312702 hasAuthorship W2466312702A5091189457 @default.
• W2466312702 hasBestOaLocation W24663127021 @default.
• W2466312702 hasConcept C126322002 @default.
• W2466312702 hasConcept C179998833 @default.
• W2466312702 hasConcept C181080969 @default.
• W2466312702 hasConcept C185592680 @default.
• W2466312702 hasConcept C190283241 @default.
• W2466312702 hasConcept C25498285 @default.
• W2466312702 hasConcept C2776741139 @default.
• W2466312702 hasConcept C2778692553 @default.
• W2466312702 hasConcept C2779066535 @default.
• W2466312702 hasConcept C43617362 @default.
• W2466312702 hasConcept C519063684 @default.
• W2466312702 hasConcept C55493867 @default.
• W2466312702 hasConcept C57074206 @default.
• W2466312702 hasConcept C62478195 @default.
• W2466312702 hasConcept C71924100 @default.
• W2466312702 hasConcept C79879829 @default.
• W2466312702 hasConcept C85520022 @default.
• W2466312702 hasConcept C86803240 @default.
• W2466312702 hasConcept C95444343 @default.
• W2466312702 hasConcept C98274493 @default.
• W2466312702 hasConceptScore W2466312702C126322002 @default.

• next